MYO5B and RAB11B

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (in vitro, two hybrid)

		MYO5B	RAB11B
Description		myosin VB	RAB11B, member RAS oncogene family
Image
GO Annotations	Cellular Component	Cytoplasm Actin Cytoskeleton Myosin Complex Cytoplasmic Vesicle Membrane Vesicle Protein-containing Complex Apical Cortex Recycling Endosome Extracellular Exosome	Endosome Cytosol Synaptic Vesicle Phagocytic Vesicle Membrane Phagocytic Vesicle Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Anchored Component Of Synaptic Vesicle Membrane
	Molecular Function	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Actin-dependent ATPase Activity Small GTPase Binding Actin Filament Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding Cadherin Binding
	Biological Process	Renal Water Homeostasis Actin Filament Organization Protein Transport Vesicle-mediated Transport Endosomal Transport Vesicle Transport Along Actin Filament	Receptor Recycling Exocytosis Melanosome Transport Transferrin Transport Insulin Secretion Involved In Cellular Response To Glucose Stimulus Post-translational Protein Modification Regulation Of Anion Transport Constitutive Secretory Pathway Regulated Exocytosis Cellular Response To Acidic PH Establishment Of Protein Localization To Membrane Amyloid-beta Clearance By Transcytosis Retrograde Transport, Endosome To Plasma Membrane Regulation Of Protein Localization To Cell Surface Regulation Of Endocytic Recycling
Pathways		Vasopressin regulates renal water homeostasis via Aquaporins	TBC/RABGAPs RAB geranylgeranylation
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549 29084231) HDL cholesterol levels ( 32203549) Large HDL particle concentration ( 29084231) Mean diameter of HDL particles ( 29084231) Medium HDL particle concentration ( 29084231) Multiple sclerosis ( 31604244) Myopia ( 27182965) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Refractive error ( 32231278) Resistant hypertension ( 31545351) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Total cholesterol levels in HDL ( 29084231)	High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494)
Interacting Genes		20 interacting genes: AMOTL2 BNIP2 COIL CXCR2 EFHC2 FAM214B GMCL1 KIAA1549 MEI4 MEOX2 POLR1C RAB11A RAB11B RAB11FIP2 RAB25 SMAD3 TCF4 TRIM3 TRIM54 ZNHIT1	11 interacting genes: APP IKBKG MEOX2 MYO5B OPTN RAB11FIP1 RAB11FIP2 RAB11FIP3 RAB11FIP5 SH3BP5L SREBF2
Entrez ID		4645	9230
HPRD ID		07582	05009
Ensembl ID		ENSG00000167306	ENSG00000185236
Uniprot IDs		Q7Z7A5 Q9ULV0	Q15907
PDB IDs		4J5M 4LNZ 4LWZ 4LX0	2F9L 2F9M 4OJK
Enriched GO Terms of Interacting Partners?
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