MEI4 and PLEKHA4

Data Source:
BioGRID (two hybrid)

		MEI4	PLEKHA4
Description		meiotic double-stranded break formation protein 4	pleckstrin homology domain containing A4
Image		No pdb structure
GO Annotations	Cellular Component	Lateral Element	Cytoplasm Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane
	Molecular Function	Protein Binding	Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	DNA Recombination Homologous Chromosome Pairing At Meiosis Spermatogenesis Meiotic DNA Double-strand Break Formation Oogenesis	Phosphatidylinositol Biosynthetic Process Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway, Planar Cell Polarity Pathway
Pathways			Synthesis of PIPs at the plasma membrane
Drugs			Inositol 1,3,4,5-Tetrakisphosphate
Diseases
GWAS		Brain volume in infants (white matter) ( 28763065) Cadmium levels ( 26025379) Macular thickness ( 30535121)	High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494 27863252) Immature fraction of reticulocytes ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		36 interacting genes: AFMID BAG4 C19orf25 C1orf109 CABP5 CDKN2D CHAF1A CPNE2 CST9L CTTNBP2 DNTT EIF5A FKBP6 GRB2 HSD3B7 IQGAP1 LGALS14 MACO1 METTL21A MLX MTMR9 MYO5B NGB NME7 OSGIN1 PAFAH1B3 PHYHIPL PLEKHA4 POLR1C R3HDM2 TRAPPC2L TRIM59 TSEN15 TSSK3 USHBP1 VPS26C	8 interacting genes: ABL1 CCNG1 EEF1G KAT5 KLHL12 LRIF1 MEI4 SETDB1
Entrez ID		101928601	57664
HPRD ID			09683
Ensembl ID		ENSG00000269964	ENSG00000105559
Uniprot IDs		A8MW99	Q9H4M7
PDB IDs			1UPQ 1UPR
Enriched GO Terms of Interacting Partners?
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