CD79A and BLNK

Number of citations of the paper that reports this interaction (PubMedID 11909947)
32

Data Source:
HPRD (in vitro, in vivo)

		CD79A	BLNK
Description		CD79a molecule	B cell linker
Image			No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane B Cell Receptor Complex Membrane Raft	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Adaptive Immune Response B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction B Cell Differentiation Intracellular Signal Transduction
Pathways		CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8	Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Interacting Genes		17 interacting genes: BLK BLNK CD19 CD5 CD79B FANCA FATE1 FCAR FYN HCLS1 IGHM JCHAIN LCK LYN PIGR PTPN6 SYK	20 interacting genes: BTK CBL CBLB CD72 CD79A CMTM3 CRKL ERBB2 GRAP2 GRB2 ITK LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1
Entrez ID		973	29760
HPRD ID		00203	05153
Ensembl ID		ENSG00000105369	ENSG00000095585
Uniprot IDs		P11912	Q2MD54 Q2MD59 Q8WV28
PDB IDs		1CV9
Enriched GO Terms of Interacting Partners?
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