BLNK

Description		B cell linker
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Ribonucleoprotein Granule
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction B Cell Differentiation Intracellular Signal Transduction
Pathways		Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Interacting Genes		20 interacting genes: BTK CBL CBLB CD72 CD79A CMTM3 CRKL ERBB2 GRAP2 GRB2 ITK LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1
Entrez ID		29760
HPRD ID		05153
Ensembl ID		ENSG00000095585
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28
PDB IDs
Enriched GO Terms of Interacting Partners?
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