BLNK and CMTM3

Number of citations of the paper that reports this interaction (PubMedID 15087455)
8

Data Source:
HPRD (in vivo, in vitro, two hybrid)

		BLNK	CMTM3
Description		B cell linker	CKLF like MARVEL transmembrane domain containing 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Ribonucleoprotein Granule	Extracellular Space Cytosol Integral Component Of Membrane Cytoplasmic Vesicle Nuclear Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding	Cytokine Activity Protein Binding
	Biological Process	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction B Cell Differentiation Intracellular Signal Transduction	Blastocyst Hatching Chemotaxis Signal Transduction Positive Regulation Of B Cell Receptor Signaling Pathway
Pathways		Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Interacting Genes		20 interacting genes: BTK CBL CBLB CD72 CD79A CMTM3 CRKL ERBB2 GRAP2 GRB2 ITK LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1	10 interacting genes: APP BLNK BTK LMNA MAPK1 MEST MOB1A MOB3C RABAC1 SPP1
Entrez ID		29760	123920
HPRD ID		05153	16259
Ensembl ID		ENSG00000095585	ENSG00000140931
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28	A0A024R6Y8 H3BUD5 Q96MX0
PDB IDs
Enriched GO Terms of Interacting Partners?
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