BLNK and GRAP2

Number of citations of the paper that reports this interaction (PubMedID 12176364)
45

Data Source:
BioGRID (unspecified method, affinity chromatography technology)
HPRD (in vivo, in vitro)

		BLNK	GRAP2
Description		B cell linker	GRB2 related adaptor protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Ribonucleoprotein Granule	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction B Cell Differentiation Intracellular Signal Transduction	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway
Pathways		Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS			Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)
Interacting Genes		20 interacting genes: BTK CBL CBLB CD72 CD79A CMTM3 CRKL ERBB2 GRAP2 GRB2 ITK LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1	66 interacting genes: BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MTUS2 PNMA1 PRPH2 RACK1 RBPMS RBX1 RIN3 RINT1 SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF526
Entrez ID		29760	9402
HPRD ID		05153	05156
Ensembl ID		ENSG00000095585	ENSG00000100351
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28	B7Z8E3 O75791 Q6FI14
PDB IDs			5GJH
Enriched GO Terms of Interacting Partners?
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