CD79A and HCLS1

Number of citations of the paper that reports this interaction (PubMedID 7927516)
2

Data Source:
HPRD (in vivo)

		CD79A	HCLS1
Description		CD79a molecule	hematopoietic cell-specific Lyn substrate 1
Image			No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane B Cell Receptor Complex Membrane Raft	Nucleus Transcription Factor Complex Cytoplasm Mitochondrion Cytosol Actin Filament Plasma Membrane Postsynaptic Density Lamellipodium Dendrite Site Of Polarized Growth Cortical Actin Cytoskeleton Postsynaptic Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding	RNA Polymerase II Transcription Factor Binding Protein Binding SH3 Domain Binding Protein Kinase Binding Actin Filament Binding
	Biological Process	Adaptive Immune Response B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Response To Hormone Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Filament Polymerization Erythrocyte Differentiation Regulation Of Actin Filament Polymerization Positive Regulation Of Granulocyte Differentiation Positive Regulation Of Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Positive Regulation Of Macrophage Differentiation Positive Regulation Of Axon Extension Positive Regulation Of Transcription By RNA Polymerase II Neuron Projection Morphogenesis Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Dendritic Spine Morphogenesis Cellular Response To Cytokine Stimulus Postsynaptic Actin Cytoskeleton Organization Negative Regulation Of Leukocyte Apoptotic Process Positive Regulation Of Actin Cytoskeleton Reorganization
Pathways		CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
Drugs
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Interacting Genes		17 interacting genes: BLK BLNK CD19 CD5 CD79B FANCA FATE1 FCAR FYN HCLS1 IGHM JCHAIN LCK LYN PIGR PTPN6 SYK	23 interacting genes: ACTA1 ACTR2 ACTR3 BLZF1 CASP3 CD79A CSNK2A1 FGR GRB2 HAX1 HS1BP3 IKBKG LYN LZTR1 MAP4K1 QKI SH2D4A SSBP3 SYK TERF1 TRIM29 WAS ZBTB25
Entrez ID		973	3059
HPRD ID		00203	03199
Ensembl ID		ENSG00000105369	ENSG00000180353
Uniprot IDs		P11912	P14317
PDB IDs		1CV9
Enriched GO Terms of Interacting Partners?
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