BLNK and ITK

Number of citations of the paper that reports this interaction (PubMedID 10556826)
63

Data Source:
HPRD (in vitro)

		BLNK	ITK
Description		B cell linker	IL2 inducible T cell kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cytoplasmic Ribonucleoprotein Granule	Nucleus Cytosol Cell-cell Junction
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Adaptor Activity SH3/SH2 Adaptor Activity Protein Binding	Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Inflammatory Response Humoral Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Signal Transduction B Cell Differentiation Intracellular Signal Transduction	Cytokine Production NK T Cell Differentiation Adaptive Immune Response Cellular Defense Response Signal Transduction Activation Of Phospholipase C Activity Interferon-gamma Production Interleukin-4 Production Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Fc-epsilon Receptor Signaling Pathway T Cell Activation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Regulation of signaling by CBL Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Generation of second messenger molecules FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization
Drugs			Staurosporine Pazopanib
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS			Daytime sleep phenotypes ( 27126917) Heel bone mineral density ( 30598549) Personality traits in bipolar disorder ( 21368711)
Interacting Genes		20 interacting genes: BTK CBL CBLB CD72 CD79A CMTM3 CRKL ERBB2 GRAP2 GRB2 ITK LCP2 MAP4K1 NCK1 PLCG1 PLCG2 PTPN6 SH3KBP1 SYK VAV1	31 interacting genes: BLNK BMX BTK CBL CD28 DOK1 EGFR ERBB2 ERBB3 FASLG FGFR1 FYN GRB2 HNRNPK IKBKG KHDRBS1 KPNA2 LAT LCK LCP2 PLCG1 PLCG2 PPIA SH2D2A SMAD4 SMURF1 SOCS1 SPRR2A SRC TGFBR1 WAS
Entrez ID		29760	3702
HPRD ID		05153	01746
Ensembl ID		ENSG00000095585	ENSG00000113263
Uniprot IDs		Q2MD54 Q2MD59 Q8WV28	Q08881
PDB IDs			1SM2 1SNU 1SNX 2E6I 2LMJ 2YUQ 3MIY 3MJ1 3MJ2 3QGW 3QGY 3T9T 3V5J 3V5L 3V8T 3V8W 4HCT 4HCU 4HCV 4KIO 4L7S 4M0Y 4M0Z 4M12 4M13 4M14 4M15 4MF0 4MF1 4PP9 4PPA 4PPB 4PPC 4PQN 4QD6 4RFM
Enriched GO Terms of Interacting Partners?
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