CD79A and JCHAIN

Number of citations of the paper that reports this interaction (PubMedID 1292512)
6

Data Source:
HPRD (in vivo)

		CD79A	JCHAIN
Description		CD79a molecule	joining chain of multimeric IgA and IgM
Image			No pdb structure
GO Annotations	Cellular Component	Multivesicular Body Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane B Cell Receptor Complex Membrane Raft	Extracellular Region Extracellular Space Extracellular Exosome Monomeric IgA Immunoglobulin Complex Dimeric IgA Immunoglobulin Complex Secretory IgA Immunoglobulin Complex Secretory Dimeric IgA Immunoglobulin Complex Pentameric IgM Immunoglobulin Complex Hexameric IgM Immunoglobulin Complex Blood Microparticle
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding	Single-stranded DNA Binding Antigen Binding IgA Binding Protein Binding, Bridging Phosphatidylcholine Binding Immunoglobulin Receptor Binding Protein Homodimerization Activity Peptidoglycan Binding
	Biological Process	Adaptive Immune Response B Cell Differentiation B Cell Proliferation B Cell Activation B Cell Receptor Signaling Pathway	Retina Homeostasis Adaptive Immune Response Glomerular Filtration Receptor-mediated Endocytosis Immune Response Humoral Immune Response Antibacterial Humoral Response Innate Immune Response Leukocyte Migration Positive Regulation Of Respiratory Burst Protein-containing Complex Assembly
Pathways		CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Cell surface interactions at the vascular wall Scavenging of heme from plasma
Drugs			Zinc
Diseases		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
GWAS
Interacting Genes		17 interacting genes: BLK BLNK CD19 CD5 CD79B FANCA FATE1 FCAR FYN HCLS1 IGHM JCHAIN LCK LYN PIGR PTPN6 SYK	2 interacting genes: CD79A IGHM
Entrez ID		973	3512
HPRD ID		00203	00991
Ensembl ID		ENSG00000105369	ENSG00000132465
Uniprot IDs		P11912	P01591
PDB IDs		1CV9
Enriched GO Terms of Interacting Partners?
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