ESPL1 and TRIM55

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		ESPL1	TRIM55
Description		extra spindle pole bodies like 1, separase	tripartite motif containing 55
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Centrosome Cytosol Mitotic Spindle	Nucleus Cytoplasm Microtubule
	Molecular Function	Catalytic Activity Cysteine-type Endopeptidase Activity Protein Binding Cysteine-type Peptidase Activity	Protein Binding Zinc Ion Binding Identical Protein Binding
	Biological Process	Mitotic Sister Chromatid Segregation Meiotic Spindle Organization Mitotic Cytokinesis Proteolysis Apoptotic Process Establishment Of Mitotic Spindle Localization Homologous Chromosome Segregation Positive Regulation Of Mitotic Metaphase/anaphase Transition Negative Regulation Of Sister Chromatid Cohesion Meiotic Chromosome Separation	Signal Transduction
Pathways		Separation of Sister Chromatids
Drugs
Diseases
GWAS		Femoral neck bone mineral density ( 29499414) Lumbar spine bone mineral density ( 29499414)	Coronary heart disease event reduction (statin therapy interaction) ( 22666496) Metabolite levels ( 23823483) Recurrent major depressive disorder ( 29317602)
Interacting Genes		7 interacting genes: MTNR1B PJA1 RFFL TRIM55 TRIM63 USP21 USP28	62 interacting genes: ACTA1 ANKRD1 ATP5F1B ATXN3 ATXN3L BRAP CKM DCAF6 DES EEF1G EHHADH EIF3E ESPL1 FHL2 FLNA FLNB FLNC GFM1 GMEB1 LMCD1 MDM4 MRPL19 MRPL41 MYBPC1 MYBPC3 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 OTUB1 OTUB2 PCGF1 PIAS1 PIAS2 PIAS3 RNF114 SQSTM1 STAM TCAP TNNI1 TNNI2 TNNI3 TRIM27 TRIM54 TRIM63 TTN UBE2D1 UBE2D2 UBE2D3 UBE2L3 UCHL3 UCHL5 USP13 USP28 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		9700	84675
HPRD ID		06825	05927
Ensembl ID		ENSG00000135476	ENSG00000147573
Uniprot IDs		Q14674	Q9BYV6
PDB IDs
Enriched GO Terms of Interacting Partners?
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