TPM2 and PDLIM7

Number of citations of the paper that reports this interaction (PubMedID 26496610)
285

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		TPM2	PDLIM7
Description		tropomyosin 2	PDZ and LIM domain 7
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton	Stress Fiber Ruffle Nucleoplasm Cytosol Adherens Junction Focal Adhesion Actin Cytoskeleton Z Disc Filamentous Actin
	Molecular Function	Actin Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Actin Binding Protein Binding Metal Ion Binding Muscle Alpha-actinin Binding
	Biological Process	Muscle Contraction Actin Filament Organization Muscle Filament Sliding Regulation Of ATPase Activity	Ossification Receptor-mediated Endocytosis Axon Guidance Heart Development Actin Cytoskeleton Organization Positive Regulation Of Osteoblast Differentiation Muscle Structure Development
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	RET signaling
Drugs
Diseases		Cap myopathy Distal arthrogryposis (DA) Nemaline myopathy
GWAS			Coronary artery disease ( 29212778) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		12 interacting genes: ACTA1 ACTB GRK2 JUN NEB PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL TPM1	34 interacting genes: AP5B1 BSG CCDC185 DGCR6 ENKD1 FNDC11 GEM GFAP HNRNPD IQGAP1 MDM2 PAK5 PCBP1 PHF1 PRKCA PRKCB PRKCZ PRKD2 PSMF1 RET SH2B2 SH3BP2 SMURF1 SPP1 TP53 TPM2 TRAF2 TRAF3 TSG101 UBE2I UBQLN4 WWP2 ZMYND11 ZNF165
Entrez ID		7169	9260
HPRD ID		11768	10436
Ensembl ID		ENSG00000198467	ENSG00000196923
Uniprot IDs		A7XZE4 P07951 Q5TCU3 V9HW25	Q9NR12
PDB IDs			2Q3G
Enriched GO Terms of Interacting Partners?
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