TPM2 and TPM1

Number of citations of the paper that reports this interaction (PubMedID 7568216)
16

Data Source:
HPRD (in vitro, in vivo)

		TPM2	TPM1
Description		tropomyosin 2	tropomyosin 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Sarcomere Bleb Ruffle Membrane
	Molecular Function	Actin Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Muscle Contraction Actin Filament Organization Muscle Filament Sliding Regulation Of ATPase Activity	In Utero Embryonic Development Positive Regulation Of Heart Rate By Epinephrine Muscle Contraction Regulation Of Muscle Contraction Cytoskeleton Organization Actin Filament Organization Regulation Of Heart Contraction Regulation Of Cell Shape Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Positive Regulation Of ATPase Activity Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Negative Regulation Of Vascular Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	Striated Muscle Contraction Smooth Muscle Contraction
Drugs			Artenimol Phenethyl Isothiocyanate
Diseases		Cap myopathy Distal arthrogryposis (DA) Nemaline myopathy	Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)
GWAS			Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mean platelet volume ( 19820697 27863252) Orofacial clefts ( 22863734) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 22139419 27863252) Platelet distribution width ( 27863252) Pulse pressure ( 27841878)
Interacting Genes		12 interacting genes: ACTA1 ACTB GRK2 JUN NEB PDLIM7 PIK3CG RRAD S100A2 S100A4 SKIL TPM1	21 interacting genes: ACTB C1orf216 CAGE1 EGFR EPB41 GOLGA2 IFIT3 JUN KXD1 MAD1L1 NEB NOD2 PKD2 S100A2 SYCE1 TFPT TMOD2 TNNT1 TNNT2 TPM2 TPM4
Entrez ID		7169	7168
HPRD ID		11768	01839
Ensembl ID		ENSG00000198467	ENSG00000140416
Uniprot IDs		A7XZE4 P07951 Q5TCU3 V9HW25	A0A024R5W6 A0A0K0K1I0 B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H0YK48 H7BYY1 O15513 P09493
PDB IDs			3MUD 5KHT
Enriched GO Terms of Interacting Partners?
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