HERC1 and UBE2S

Number of citations of the paper that reports this interaction (PubMedID 26949039)
51

Data Source:
BioGRID (pull down)

		HERC1	UBE2S
Description		HECT and RLD domain containing E3 ubiquitin protein ligase family member 1	ubiquitin conjugating enzyme E2 S
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GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Membrane	Cell Nucleoplasm Anaphase-promoting Complex Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity ARF Guanyl-nucleotide Exchange Factor Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Anaphase-promoting Complex Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Autophagy Protein Ubiquitination Cerebellar Purkinje Cell Differentiation Corpus Callosum Development Neuron Projection Development Neuromuscular Process Controlling Balance	Protein Polyubiquitination Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Exit From Mitosis Free Ubiquitin Chain Polymerization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Protein K29-linked Ubiquitination Protein K27-linked Ubiquitination Cell Division Protein K63-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Atrial fibrillation ( 30061737) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Glucagon levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Iris characteristics ( 21835309) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		12 interacting genes: BAK1 EP300 LAPTM5 PKM RAF1 RNF11 SOX9 UBC UBE2D2 UBE2D3 UBE2L3 UBE2S	40 interacting genes: AKT1 ANAPC1 ANAPC11 ANAPC2 ANAPC4 ANAPC5 ANAPC7 APP ATXN3 BIRC2 CDC16 CDC20 CDC23 CDC27 CTNNB1 CYLD FBXO5 FZR1 GMNN HERC1 LINC00839 MDM2 OTUB1 OTUD7B PRKN PTEN RBCK1 RNF7 STAMBP UBA1 UBA6 UBB UBC UCHL3 USP15 USP2 USP21 USP5 USP7 ZRANB1
Entrez ID		8925	27338
HPRD ID		06894	15603
Ensembl ID		ENSG00000103657	ENSG00000108106
Uniprot IDs		A0A024R5W0 Q15751	Q16763
PDB IDs		4O2W 4QT6	1ZDN 5BNB 5L9T 6QH3 6QHK
Enriched GO Terms of Interacting Partners?
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