QARS1 and NLGN3

Number of citations of the paper that reports this interaction (PubMedID 25464930)
5

Data Source:
BioGRID (two hybrid)

		QARS1	NLGN3
Description		glutaminyl-tRNA synthetase 1	neuroligin 3
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Cytosol Aminoacyl-tRNA Synthetase Multienzyme Complex Protein-containing Complex	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Cell Junction Endocytic Vesicle Synapse Excitatory Synapse Spanning Component Of Membrane Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Asymmetric, Glutamatergic, Excitatory Synapse Integral Component Of Postsynaptic Membrane
	Molecular Function	Glutamine-tRNA Ligase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Protein Kinase Binding	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glutaminyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Brain Development Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Receptor-mediated Endocytosis Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Visual Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Oligodendrocyte Differentiation Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Long-term Synaptic Potentiation Negative Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Negative Regulation Of Excitatory Postsynaptic Potential Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Regulation Of Long-term Synaptic Potentiation Regulation Of NMDA Receptor Activity Regulation Of Terminal Button Organization Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering Positive Regulation Of AMPA Receptor Activity
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	Neurexins and neuroligins Neurexins and neuroligins
Drugs
Diseases
GWAS			Prostate cancer ( 25217961)
Interacting Genes		39 interacting genes: ACTN2 ANXA7 APP ASL CDK4 CDKN1A CLTC CPNE3 DPPA4 DTX2 DUSP11 FAM118B GADD45A GSK3B H2AX IRF1 KCNE3 KLC3 LAMTOR3 LZTS2 MAP3K5 NLGN3 PIK3R3 PIN1 PRRC2A RARS1 RNF11 SMAD9 SMN1 STK3 TCF12 TK1 TLE5 TRAF2 TRAF4 TRIP13 TSC22D1 TTR VPS37B	56 interacting genes: ALPP AP2A2 ATF4 C1orf122 C1QA CCAR2 CGB3 CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12 PDZD11 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 SPAG5 SPINT1 SSR4 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1
Entrez ID		5859	54413
HPRD ID		07223	02275
Ensembl ID		ENSG00000172053	ENSG00000196338
Uniprot IDs		B7Z840 P47897	B7Z3P8 Q4G160 Q6MZK0 Q9NZ94 X5D2P6 X5D7L6 X5DNV3
PDB IDs		4R3Z 4YE6 4YE8 4YE9
Enriched GO Terms of Interacting Partners?
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