QARS1 and IRF1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		QARS1	IRF1
Description		glutaminyl-tRNA synthetase 1	interferon regulatory factor 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Cytosol Aminoacyl-tRNA Synthetase Multienzyme Complex Protein-containing Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Glutamine-tRNA Ligase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Protein Kinase Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glutaminyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Brain Development Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway	Immune System Process Regulation Of Adaptive Immune Response Transcription By RNA Polymerase II Apoptotic Process Cell Cycle Arrest Blood Coagulation Negative Regulation Of Cell Proliferation Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Interferon-beta CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Innate Immune Response Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Regulation Of Cell Cycle Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Mechanical Stimulus Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Asthma ( 30929738 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433) Asthma (sex interaction) ( 24824216) Asthma or allergic disease (pleiotropy) ( 29785011) C-reactive protein levels ( 21300955) Crohn's disease ( 28067908 21102463) Diastolic blood pressure ( 27841878) Fibrinogen ( 20031576 20031577 23969696) Inflammatory bowel disease ( 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Platelet count ( 22139419) Plateletcrit ( 27863252) Polycystic ovary syndrome ( 30566500) Ulcerative colitis ( 28067908)
Interacting Genes		39 interacting genes: ACTN2 ANXA7 APP ASL CDK4 CDKN1A CLTC CPNE3 DPPA4 DTX2 DUSP11 FAM118B GADD45A GSK3B H2AX IRF1 KCNE3 KLC3 LAMTOR3 LZTS2 MAP3K5 NLGN3 PIK3R3 PIN1 PRRC2A RARS1 RNF11 SMAD9 SMN1 STK3 TCF12 TK1 TLE5 TRAF2 TRAF4 TRIP13 TSC22D1 TTR VPS37B	22 interacting genes: CDKN1B CREBBP EP300 GSK3B HMGA1 IRF2 IRF8 IRF9 KAT2A KAT2B KEAP1 MDM2 NFKB1 NPM1 QARS1 RELA SET SPI1 STAT1 TRAF3 TRIM28 YBX1
Entrez ID		5859	3659
HPRD ID		07223	00961
Ensembl ID		ENSG00000172053	ENSG00000125347
Uniprot IDs		B7Z840 P47897	P10914 Q6FHN8
PDB IDs		4R3Z 4YE6 4YE8 4YE9
Enriched GO Terms of Interacting Partners?
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