QARS1 and DPPA4

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		QARS1	DPPA4
Description		glutaminyl-tRNA synthetase 1	developmental pluripotency associated 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Cytosol Aminoacyl-tRNA Synthetase Multienzyme Complex Protein-containing Complex	Nucleoplasm
	Molecular Function	Glutamine-tRNA Ligase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Protein Kinase Binding	Chromatin Binding Protein Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glutaminyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Brain Development Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway	Somatic Stem Cell Population Maintenance Lung-associated Mesenchyme Development
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation
Drugs
Diseases
GWAS			Cardiac hypertrophy ( 21348951) Corneal astigmatism ( 23761726) Metabolite levels ( 23823483)
Interacting Genes		39 interacting genes: ACTN2 ANXA7 APP ASL CDK4 CDKN1A CLTC CPNE3 DPPA4 DTX2 DUSP11 FAM118B GADD45A GSK3B H2AX IRF1 KCNE3 KLC3 LAMTOR3 LZTS2 MAP3K5 NLGN3 PIK3R3 PIN1 PRRC2A RARS1 RNF11 SMAD9 SMN1 STK3 TCF12 TK1 TLE5 TRAF2 TRAF4 TRIP13 TSC22D1 TTR VPS37B	18 interacting genes: BTBD2 CRK DPPA2 EIF4A2 EMD GRB2 HTT LDOC1 MAPK6 PLEKHF2 PTPRO QARS1 RPGRIP1 RPS6KB1 SH3GL1 SH3GL2 SH3GL3 VIM
Entrez ID		5859	55211
HPRD ID		07223	16836
Ensembl ID		ENSG00000172053	ENSG00000121570
Uniprot IDs		B7Z840 P47897	Q7L190
PDB IDs		4R3Z 4YE6 4YE8 4YE9
Enriched GO Terms of Interacting Partners?
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