NLGN3 and C1QA

Number of citations of the paper that reports this interaction (PubMedID 25464930)
5

Data Source:
BioGRID (two hybrid)

		NLGN3	C1QA
Description		neuroligin 3	complement C1q A chain
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Cell Junction Endocytic Vesicle Synapse Excitatory Synapse Spanning Component Of Membrane Presynapse Symmetric, GABA-ergic, Inhibitory Synapse Asymmetric, Glutamatergic, Excitatory Synapse Integral Component Of Postsynaptic Membrane	Extracellular Region Collagen Trimer Complement Component C1 Complex Cell Synapse Collagen-containing Extracellular Matrix Postsynapse
	Molecular Function	Protein Binding Signaling Receptor Activity Neurexin Family Protein Binding Cell Adhesion Molecule Binding Scaffold Protein Binding	Amyloid-beta Binding Protein Binding
	Biological Process	Regulation Of Respiratory Gaseous Exchange By Neurological System Process Receptor-mediated Endocytosis Neuron Cell-cell Adhesion Chemical Synaptic Transmission Synapse Assembly Learning Visual Learning Adult Behavior Social Behavior Synaptic Vesicle Endocytosis Axon Extension Oligodendrocyte Differentiation Modulation Of Chemical Synaptic Transmission Synapse Organization Positive Regulation Of Synapse Assembly Positive Regulation Of Synaptic Transmission, Glutamatergic Rhythmic Synaptic Transmission Excitatory Postsynaptic Potential Inhibitory Postsynaptic Potential Long-term Synaptic Potentiation Negative Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Negative Regulation Of Excitatory Postsynaptic Potential Postsynaptic Membrane Assembly Presynaptic Membrane Assembly Presynapse Assembly Regulation Of Long-term Synaptic Potentiation Regulation Of NMDA Receptor Activity Regulation Of Terminal Button Organization Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Clustering Positive Regulation Of AMPA Receptor Activity	Microglial Cell Activation Complement Activation Complement Activation, Classical Pathway Cell-cell Signaling Aging Response To Iron Ion Viral Process Neuron Remodeling Regulation Of Complement Activation Innate Immune Response Astrocyte Activation Synapse Organization Synapse Pruning Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Positive Regulation Of Neuron Death
Pathways		Neurexins and neuroligins Neurexins and neuroligins	Initial triggering of complement Classical antibody-mediated complement activation Regulation of Complement cascade
Drugs			Cetuximab Etanercept Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab
Diseases			Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		Prostate cancer ( 25217961)
Interacting Genes		56 interacting genes: ALPP AP2A2 ATF4 C1orf122 C1QA CCAR2 CGB3 CTSD DLG2 DLG3 DLG4 DPEP2 EBPL EFS FANCG FBLN1 FHOD1 FKBP1A FLNA GDF15 GUK1 HID1 ITPRIP LGALS1 MAN2C1 MAP1S MEOX2 MIEN1 NFATC4 NRDC NRXN1 NRXN2 NRXN3 OAZ1 OR1F12 PDZD11 PKIB PLB1 PLCB4 PRDX2 PSAP PSG1 PSG11 PSG3 PSG4 PSG5 QARS1 SPAG5 SPINT1 SSR4 TNNT3 TRIM33 TXNIP UBQLN1 UBXN6 UQCRC1	28 interacting genes: APCS BAG6 C1QB C1QBP C1QC C1R C1S CD93 COL2A1 CR1 CRP CSPG4 DCN FN1 GNPNAT1 HIPK3 HRG HSPB2 NLGN3 PIAS2 PPP1CA PPP1CC PTX3 RHOA SGTA SLC25A47 UBQLN1 UBQLN2
Entrez ID		54413	712
HPRD ID		02275	00393
Ensembl ID		ENSG00000196338	ENSG00000173372
Uniprot IDs		B7Z3P8 Q4G160 Q6MZK0 Q9NZ94 X5D2P6 X5D7L6 X5DNV3	A0A024RAG6 P02745
PDB IDs			1PK6 2JG8 2JG9 2WNU 2WNV 5HKJ 5HZF 6FCZ
Enriched GO Terms of Interacting Partners?
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