QARS1 and STK3

Number of citations of the paper that reports this interaction (PubMedID 21900206)
114

Data Source:
BioGRID (two hybrid)

		QARS1	STK3
Description		glutaminyl-tRNA synthetase 1	serine/threonine kinase 3
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrial Matrix Cytosol Aminoacyl-tRNA Synthetase Multienzyme Complex Protein-containing Complex	Nucleus Cytoplasm Cytosol Protein-containing Complex
	Molecular Function	Glutamine-tRNA Ligase Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Protein Kinase Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Identical Protein Binding Protein Serine/threonine Kinase Activator Activity
	Biological Process	TRNA Aminoacylation For Protein Translation Glutaminyl-tRNA Aminoacylation Negative Regulation Of Protein Kinase Activity Brain Development Negative Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Apoptotic Signaling Pathway	Neural Tube Formation Endocardium Development Protein Phosphorylation Apoptotic Process Signal Transduction Regulation Of Mitotic Cell Cycle Central Nervous System Development Negative Regulation Of Cell Proliferation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Protein Binding Activation Of Protein Kinase Activity Hippo Signaling Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of Fat Cell Differentiation Positive Regulation Of JNK Cascade Negative Regulation Of Organ Growth Neuron Projection Morphogenesis Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Protein Kinase B Signaling Primitive Hemopoiesis Cell Differentiation Involved In Embryonic Placenta Development Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Positive Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Canonical Wnt Signaling Pathway Hepatocyte Apoptotic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation	Signaling by Hippo
Drugs
Diseases
GWAS			Depressive symptom improvement ( 30468137) Heel bone mineral density ( 30598549) Rosacea symptom severity ( 29771307) Suicide behavior ( 26079190)
Interacting Genes		39 interacting genes: ACTN2 ANXA7 APP ASL CDK4 CDKN1A CLTC CPNE3 DPPA4 DTX2 DUSP11 FAM118B GADD45A GSK3B H2AX IRF1 KCNE3 KLC3 LAMTOR3 LZTS2 MAP3K5 NLGN3 PIK3R3 PIN1 PRRC2A RARS1 RNF11 SMAD9 SMN1 STK3 TCF12 TK1 TLE5 TRAF2 TRAF4 TRIP13 TSC22D1 TTR VPS37B	34 interacting genes: AKT1 CASP3 CDK1 CNKSR1 CPNE1 DDAH2 EIF4EBP1 FAM9B GAD1 GBP2 GMCL1 HSPE1 KEAP1 KHSRP LATS1 LATS2 LRRK2 MBP MOB4 MPP1 ORM2 PEX19 PHAX PLK1 QARS1 RAF1 RASSF1 SAV1 SLMAP STK4 SULT2A1 TFPT TRAF1 ZC3H7A
Entrez ID		5859	6788
HPRD ID		07223	05433
Ensembl ID		ENSG00000172053	ENSG00000104375
Uniprot IDs		B7Z840 P47897	A0A087WZ06 A0A384MR07 Q13188
PDB IDs		4R3Z 4YE6 4YE8 4YE9	3WWS 4HKD 4L0N 4LG4 4LGD 4OH9 5BRM 5DH3 6AO5 6AR2
Enriched GO Terms of Interacting Partners?
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