IRF1 and IRF2

Number of citations of the paper that reports this interaction (PubMedID 16982896)
9

Data Source:
BioGRID (pull down)

		IRF1	IRF2
Description		interferon regulatory factor 1	interferon regulatory factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Immune System Process Regulation Of Adaptive Immune Response Transcription By RNA Polymerase II Apoptotic Process Cell Cycle Arrest Blood Coagulation Negative Regulation Of Cell Proliferation Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Interferon-beta CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Innate Immune Response Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Regulation Of Cell Cycle Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Mechanical Stimulus Regulation Of CD8-positive, Alpha-beta T Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription, DNA-templated Blood Coagulation Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways		Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production	Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Asthma ( 30929738 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433) Asthma (sex interaction) ( 24824216) Asthma or allergic disease (pleiotropy) ( 29785011) C-reactive protein levels ( 21300955) Crohn's disease ( 28067908 21102463) Diastolic blood pressure ( 27841878) Fibrinogen ( 20031576 20031577 23969696) Inflammatory bowel disease ( 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Platelet count ( 22139419) Plateletcrit ( 27863252) Polycystic ovary syndrome ( 30566500) Ulcerative colitis ( 28067908)	Acute kidney injury in critical illness ( 27576016) Adverse response to drug ( 30420678) Chronic lymphocytic leukemia ( 28165464) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lewy body disease ( 25188341) Night sleep phenotypes ( 27126917) Nonsyndromic cleft lip ( 31609978)
Interacting Genes		22 interacting genes: CDKN1B CREBBP EP300 GSK3B HMGA1 IRF2 IRF8 IRF9 KAT2A KAT2B KEAP1 MDM2 NFKB1 NPM1 QARS1 RELA SET SPI1 STAT1 TRAF3 TRIM28 YBX1	22 interacting genes: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 HMGB1 HMGN1 IRF1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFKB1 PPP3CB PRKACA RELA SPI1 STAT1
Entrez ID		3659	3660
HPRD ID		00961	00962
Ensembl ID		ENSG00000125347	ENSG00000168310
Uniprot IDs		P10914 Q6FHN8	P14316
PDB IDs
Enriched GO Terms of Interacting Partners?
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