IRF1 and SPI1

Number of citations of the paper that reports this interaction (PubMedID 11483597)
21

Data Source:
BioGRID (pull down)

		IRF1	SPI1
Description		interferon regulatory factor 1	Spi-1 proto-oncogene
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Binding Protein Binding Transcription Factor Binding NFAT Protein Binding
	Biological Process	Immune System Process Regulation Of Adaptive Immune Response Transcription By RNA Polymerase II Apoptotic Process Cell Cycle Arrest Blood Coagulation Negative Regulation Of Cell Proliferation Positive Regulation Of Type I Interferon Production Positive Regulation Of Interferon-beta Production Regulation Of MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To Interferon-beta CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Innate Immune Response Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Regulation Of Cell Cycle Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Mechanical Stimulus Regulation Of CD8-positive, Alpha-beta T Cell Proliferation	Negative Regulation Of Transcription By RNA Polymerase II Lymphoid Progenitor Cell Differentiation Regulation Of Transcription By RNA Polymerase II Lymphocyte Differentiation Cell Differentiation Erythrocyte Differentiation Macrophage Differentiation Granulocyte Differentiation Somatic Stem Cell Population Maintenance Myeloid Dendritic Cell Differentiation Histone H3 Acetylation Hypermethylation Of CpG Island Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Erythrocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Regression Pri-miRNA Transcription By RNA Polymerase II Interleukin-6-mediated Signaling Pathway Cellular Response To Ethanol Negative Regulation Of Histone H4 Acetylation Apoptotic Process Involved In Blood Vessel Morphogenesis Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Pathways		Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production	RUNX1 regulates transcription of genes involved in differentiation of HSCs Transcriptional regulation of granulopoiesis Transcriptional regulation of granulopoiesis
Drugs
Diseases			Acute myeloid leukemia (AML)
GWAS		Asthma ( 30929738 31619474 29273806) Asthma (adult onset) ( 31036433 30929738) Asthma (childhood onset) ( 31036433) Asthma (sex interaction) ( 24824216) Asthma or allergic disease (pleiotropy) ( 29785011) C-reactive protein levels ( 21300955) Crohn's disease ( 28067908 21102463) Diastolic blood pressure ( 27841878) Fibrinogen ( 20031576 20031577 23969696) Inflammatory bowel disease ( 28067908 23128233) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Platelet count ( 22139419) Plateletcrit ( 27863252) Polycystic ovary syndrome ( 30566500) Ulcerative colitis ( 28067908)	Alcohol use disorder (total score) ( 30336701) Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Blood urea nitrogen levels ( 31152163) C-reactive protein levels ( 30388399) Estimated glomerular filtration rate ( 31152163) Experiencing mood swings ( 29500382) Familial squamous cell lung carcinoma ( 29924316) Global electrical heterogeneity phenotypes ( 29622589) Hematology traits ( 30576415) Intraocular pressure ( 29617998 25173106) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Medication use (diuretics) ( 31015401) Neuroticism ( 29255261)
Interacting Genes		22 interacting genes: CDKN1B CREBBP EP300 GSK3B HMGA1 IRF2 IRF8 IRF9 KAT2A KAT2B KEAP1 MDM2 NFKB1 NPM1 QARS1 RELA SET SPI1 STAT1 TRAF3 TRIM28 YBX1	45 interacting genes: ATF1 BCL6 CEBPA CEBPB CEBPD CEBPE CREBBP CREM CSNK2A1 DNMT3A DNMT3B ERG ETS1 ETS2 ETV1 FOS FUS GATA1 GATA2 GATA3 GFI1 HDAC1 HOXA10 IRF1 IRF2 IRF4 IRF8 JUN KAT6A MAPK8 MECP2 MITF NFATC1 NFKB1 NFYA NONO PIP RB1 RUNX1 SIN3A SKI SPIB SSRP1 TBP TMX1
Entrez ID		3659	6688
HPRD ID		00961	01305
Ensembl ID		ENSG00000125347	ENSG00000066336
Uniprot IDs		P10914 Q6FHN8	P17947
PDB IDs
Enriched GO Terms of Interacting Partners?
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