ITGB1 and FHL2

Number of citations of the paper that reports this interaction (PubMedID 10906324)
29

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vitro)

		ITGB1	FHL2
Description		integrin subunit beta 1	four and a half LIM domains 2
Image
GO Annotations	Cellular Component	Ruffle Cell Cytoplasm Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Intercalated Disc Membrane Lamellipodium Filopodium Neuromuscular Junction Cleavage Furrow Ruffle Membrane Protein-containing Complex Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Dendritic Spine Receptor Complex Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Invadopodium Membrane Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Synaptic Membrane	Nucleus Nucleoplasm Focal Adhesion Z Disc M Band
	Molecular Function	Virus Receptor Activity Fibronectin Binding Protease Binding Actin Binding Integrin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Collagen Binding Involved In Cell-matrix Adhesion Protein Tyrosine Kinase Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding Metal Ion Binding Androgen Receptor Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation In Utero Embryonic Development Cell Fate Specification Cell Migration Involved In Sprouting Angiogenesis Phagocytosis Cellular Defense Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Germ Cell Migration Visual Learning Regulation Of Collagen Catabolic Process Positive Regulation Of Fibroblast Migration Cell Migration Cytokine-mediated Signaling Pathway Formation Of Radial Glial Scaffolds CD40 Signaling Pathway Cell Projection Organization Lamellipodium Assembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Cell-substrate Adhesion Receptor Internalization Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of GTPase Activity Sarcomere Organization Negative Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Viral Entry Into Host Cell Mesodermal Cell Differentiation Axon Extension Dendrite Morphogenesis Regulation Of Immune Response Modulation Of Chemical Synaptic Transmission Leukocyte Migration Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Cellular Response To Low-density Lipoprotein Particle Stimulus Basement Membrane Organization Positive Regulation Of Wound Healing Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Anoikis	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Response To Hormone Regulation Of Lipid Metabolic Process Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Elastic fibre formation Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Basigin interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans Other semaphorin interactions Signal transduction by L1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions CHL1 interactions RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen MET activates PTK2 signaling MET interacts with TNS proteins HCMV Early Events	PPARA activates gene expression
Drugs		Antithymocyte immunoglobulin (rabbit)
Diseases
GWAS		Depression (quantitative trait) ( 20800221) Suicide in bipolar disorder ( 25917933)	Body fat mass ( 28552196) Household income (MTAG) ( 31844048) Lung cancer in ever smokers ( 28604730) Pulse pressure ( 30224653 30578418)
Interacting Genes		78 interacting genes: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD36 CD46 CD82 CD9 CRKL DAG1 DOK1 EFNA4 EGFR EPS8 FBLN1 FBXO2 FERMT1 FERMT2 FERMT3 FHL2 FLNA FLNB FLT4 FN1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LGALS1 LGALS3BP LGALS8 MAP4K4 MET NCKIPSD NF2 NME1 NMRK2 PDHB PIP5K1C PLAUR PRKCA PRKCE PTK2 PXN RAB25 RACK1 SLC3A2 SPP1 TGFBR1 TGM2 TGOLN2 TIMP2 TLN1 TNC TSPAN4 UPF2 VCAM1 VCAN YWHAB ZEB1 ZNF33A	98 interacting genes: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BIN1 BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EP300 ESR1 FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HCK HSPB2 ID3 IDH1 IER3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MDM2 MYBPC1 NIBAN1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SAXO1 SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 SUMO1P1 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZBTB25 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638
Entrez ID		3688	2274
HPRD ID		00628	04026
Ensembl ID		ENSG00000150093	ENSG00000115641
Uniprot IDs		P05556	Q14192 Q2XQU9 Q6I9R8
PDB IDs		1K11 1LHA 3G9W 3T9K 3VI3 3VI4 4DX9 4WJK 4WK0 4WK2 4WK4	1X4K 1X4L 2D8Z 2MIU
Enriched GO Terms of Interacting Partners?
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