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ITGB1 and SPP1
Number of citations of the paper that reports this interaction (PubMedID
10593924
)
76
Data Source:
HPRD
(in vivo, in vitro)
ITGB1
SPP1
Description
integrin subunit beta 1
secreted phosphoprotein 1
Image
GO Annotations
Cellular Component
Ruffle
Cell
Cytoplasm
Plasma Membrane
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Intercalated Disc
Membrane
Lamellipodium
Filopodium
Neuromuscular Junction
Cleavage Furrow
Ruffle Membrane
Protein-containing Complex
Integrin Alpha1-beta1 Complex
Integrin Alpha2-beta1 Complex
Integrin Alpha3-beta1 Complex
Integrin Alpha5-beta1 Complex
Integrin Alpha7-beta1 Complex
Integrin Alpha8-beta1 Complex
Integrin Alpha10-beta1 Complex
Integrin Alpha11-beta1 Complex
Myelin Sheath Abaxonal Region
Sarcolemma
Melanosome
Dendritic Spine
Receptor Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Recycling Endosome
Extracellular Exosome
Invadopodium Membrane
Glial Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Integral Component Of Synaptic Membrane
Extracellular Region
Extracellular Space
Endoplasmic Reticulum Lumen
Golgi Apparatus
Cell Projection
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Molecular Function
Virus Receptor Activity
Fibronectin Binding
Protease Binding
Actin Binding
Integrin Binding
Protein Binding
Coreceptor Activity
C-X3-C Chemokine Binding
Laminin Binding
Protein-containing Complex Binding
Cadherin Binding
Metal Ion Binding
Protein Heterodimerization Activity
Cell Adhesion Molecule Binding
Collagen Binding Involved In Cell-matrix Adhesion
Protein Tyrosine Kinase Binding
Cytokine Activity
Integrin Binding
Protein Binding
Extracellular Matrix Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Establishment Of Mitotic Spindle Orientation
In Utero Embryonic Development
Cell Fate Specification
Cell Migration Involved In Sprouting Angiogenesis
Phagocytosis
Cellular Defense Response
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Positive Regulation Of Cell Proliferation
Germ Cell Migration
Visual Learning
Regulation Of Collagen Catabolic Process
Positive Regulation Of Fibroblast Migration
Cell Migration
Cytokine-mediated Signaling Pathway
Formation Of Radial Glial Scaffolds
CD40 Signaling Pathway
Cell Projection Organization
Lamellipodium Assembly
B Cell Differentiation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Cell-substrate Adhesion
Receptor Internalization
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Negative Regulation Of Rho Protein Signal Transduction
Positive Regulation Of Apoptotic Process
Stress Fiber Assembly
Positive Regulation Of GTPase Activity
Sarcomere Organization
Negative Regulation Of Cell Differentiation
Positive Regulation Of Angiogenesis
Viral Entry Into Host Cell
Mesodermal Cell Differentiation
Axon Extension
Dendrite Morphogenesis
Regulation Of Immune Response
Modulation Of Chemical Synaptic Transmission
Leukocyte Migration
Leukocyte Tethering Or Rolling
Regulation Of Cell Cycle
Positive Regulation Of Protein Kinase B Signaling
Cardiac Muscle Cell Differentiation
Cellular Response To Low-density Lipoprotein Particle Stimulus
Basement Membrane Organization
Positive Regulation Of Wound Healing
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Anoikis
Osteoblast Differentiation
Androgen Catabolic Process
Inflammatory Response
Cell Adhesion
Signal Transduction
Embryo Implantation
Extracellular Matrix Organization
Biomineral Tissue Development
Response To Vitamin D
Post-translational Protein Modification
Cellular Protein Metabolic Process
Positive Regulation Of Bone Resorption
Positive Regulation Of Transcription, DNA-templated
Decidualization
Response To Steroid Hormone
Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury
Cellular Response To Testosterone Stimulus
Positive Regulation Of Estradiol Secretion
Pathways
Elastic fibre formation
Fibronectin matrix formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Basigin interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Integrin cell surface interactions
Laminin interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
Other semaphorin interactions
Signal transduction by L1
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
CHL1 interactions
RHO GTPases Activate Formins
Interleukin-4 and Interleukin-13 signaling
Platelet Adhesion to exposed collagen
MET activates PTK2 signaling
MET interacts with TNS proteins
HCMV Early Events
Degradation of the extracellular matrix
Signaling by PDGF
Integrin cell surface interactions
Integrin cell surface interactions
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
RUNX3 Regulates Immune Response and Cell Migration
Post-translational protein phosphorylation
Drugs
Antithymocyte immunoglobulin (rabbit)
Diseases
GWAS
Depression (quantitative trait) (
20800221
)
Suicide in bipolar disorder (
25917933
)
Blood protein levels (
30072576
)
Dental caries (
23064961
)
Urate levels (
31578528
)
Interacting Genes
78 interacting genes:
ACAP1
ACTN1
ACTN4
ARHGAP5
CANX
CD151
CD36
CD46
CD82
CD9
CRKL
DAG1
DOK1
EFNA4
EGFR
EPS8
FBLN1
FBXO2
FERMT1
FERMT2
FERMT3
FHL2
FLNA
FLNB
FLT4
FN1
HSPD1
HSPG2
ICAM4
IGF1R
ILK
ITGA1
ITGA10
ITGA11
ITGA2
ITGA3
ITGA4
ITGA5
ITGA6
ITGA8
ITGA9
ITGAV
ITGB1BP1
ITGB1BP2
LAMA1
LGALS1
LGALS3BP
LGALS8
MAP4K4
MET
NCKIPSD
NF2
NME1
NMRK2
PDHB
PIP5K1C
PLAUR
PRKCA
PRKCE
PTK2
PXN
RAB25
RACK1
SLC3A2
SPP1
TGFBR1
TGM2
TGOLN2
TIMP2
TLN1
TNC
TSPAN4
UPF2
VCAM1
VCAN
YWHAB
ZEB1
ZNF33A
89 interacting genes:
ABCF3
ACP5
AFF4
AMOTL2
APOA1
ATP2A2
ATP5PB
BAG6
BRD3
C1RL
C2orf50
CACNG4
CALM1
CC2D1B
CD44
CEP162
CHD1
CISD2
CMTM3
COMMD1
COPS5
CSNK2A1
CSNK2A2
CTNNBL1
CYB5R3
DCX
DNAJB1
DNTTIP2
DSEL
EEF1A1
EIF3K
EPAS1
F2
FTH1
GRIPAP1
HBA2
HMGN1
IGFBP5
ITGA5
ITGA9
ITGAV
ITGB1
ITGB5
KCNIP1
LRRC4
MAP1A
MAP1B
MARCKS
MEOX2
MMP3
MMP7
MPPED1
MRPL23
NACA
NCKAP1
NCSTN
PDLIM7
PEMT
PEPD
PLD3
PRKACB
PRKCA
PRKG1
RANBP9
RAPGEF2
RBBP6
RIMS4
RPL13
RPL15
RPL5
RPS13
SEC24C
SGTA
SLC39A6
SNAPIN
SSB
STAU1
STK39
TBC1D8
TMEM168
TMEM30A
TPT1
TTC1
TUBB
UBQLN4
USP42
USP8
ZNF638
ZNF804A
Entrez ID
3688
6696
HPRD ID
00628
01325
Ensembl ID
ENSG00000150093
ENSG00000118785
Uniprot IDs
P05556
A0A024RDE2
A0A024RDE6
A0A024RDJ0
B7Z351
P10451
Q3LGB0
PDB IDs
1K11
1LHA
3G9W
3T9K
3VI3
3VI4
4DX9
4WJK
4WK0
4WK2
4WK4
3CXD
3DSF
Enriched GO Terms of Interacting Partners
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