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ITGB1 and FLT4
Number of citations of the paper that reports this interaction (PubMedID
11553610
)
23
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
ITGB1
FLT4
Description
integrin subunit beta 1
fms related receptor tyrosine kinase 4
Image
GO Annotations
Cellular Component
Ruffle
Cell
Cytoplasm
Plasma Membrane
Focal Adhesion
Integrin Complex
External Side Of Plasma Membrane
Cell Surface
Intercalated Disc
Membrane
Lamellipodium
Filopodium
Neuromuscular Junction
Cleavage Furrow
Ruffle Membrane
Protein-containing Complex
Integrin Alpha1-beta1 Complex
Integrin Alpha2-beta1 Complex
Integrin Alpha3-beta1 Complex
Integrin Alpha5-beta1 Complex
Integrin Alpha7-beta1 Complex
Integrin Alpha8-beta1 Complex
Integrin Alpha10-beta1 Complex
Integrin Alpha11-beta1 Complex
Myelin Sheath Abaxonal Region
Sarcolemma
Melanosome
Dendritic Spine
Receptor Complex
Membrane Raft
Perinuclear Region Of Cytoplasm
Recycling Endosome
Extracellular Exosome
Invadopodium Membrane
Glial Cell Projection
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Integral Component Of Synaptic Membrane
Extracellular Region
Nucleoplasm
Cytoplasm
Plasma Membrane
Integral Component Of Plasma Membrane
Receptor Complex
Molecular Function
Virus Receptor Activity
Fibronectin Binding
Protease Binding
Actin Binding
Integrin Binding
Protein Binding
Coreceptor Activity
C-X3-C Chemokine Binding
Laminin Binding
Protein-containing Complex Binding
Cadherin Binding
Metal Ion Binding
Protein Heterodimerization Activity
Cell Adhesion Molecule Binding
Collagen Binding Involved In Cell-matrix Adhesion
Protein Tyrosine Kinase Binding
Transmembrane Receptor Protein Tyrosine Kinase Activity
Vascular Endothelial Growth Factor-activated Receptor Activity
Protein Binding
ATP Binding
Growth Factor Binding
Protein Phosphatase Binding
VEGF-C-activated Receptor Activity
Vascular Endothelial Growth Factor Binding
Protein Homodimerization Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Establishment Of Mitotic Spindle Orientation
In Utero Embryonic Development
Cell Fate Specification
Cell Migration Involved In Sprouting Angiogenesis
Phagocytosis
Cellular Defense Response
Cell Adhesion
Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
Leukocyte Cell-cell Adhesion
Cell-matrix Adhesion
Calcium-independent Cell-matrix Adhesion
Transforming Growth Factor Beta Receptor Signaling Pathway
Integrin-mediated Signaling Pathway
Positive Regulation Of Cell Proliferation
Germ Cell Migration
Visual Learning
Regulation Of Collagen Catabolic Process
Positive Regulation Of Fibroblast Migration
Cell Migration
Cytokine-mediated Signaling Pathway
Formation Of Radial Glial Scaffolds
CD40 Signaling Pathway
Cell Projection Organization
Lamellipodium Assembly
B Cell Differentiation
Extracellular Matrix Organization
Positive Regulation Of Cell Migration
Cell-substrate Adhesion
Receptor Internalization
Cell Adhesion Mediated By Integrin
Cell-cell Adhesion Mediated By Integrin
Heterotypic Cell-cell Adhesion
Negative Regulation Of Rho Protein Signal Transduction
Positive Regulation Of Apoptotic Process
Stress Fiber Assembly
Positive Regulation Of GTPase Activity
Sarcomere Organization
Negative Regulation Of Cell Differentiation
Positive Regulation Of Angiogenesis
Viral Entry Into Host Cell
Mesodermal Cell Differentiation
Axon Extension
Dendrite Morphogenesis
Regulation Of Immune Response
Modulation Of Chemical Synaptic Transmission
Leukocyte Migration
Leukocyte Tethering Or Rolling
Regulation Of Cell Cycle
Positive Regulation Of Protein Kinase B Signaling
Cardiac Muscle Cell Differentiation
Cellular Response To Low-density Lipoprotein Particle Stimulus
Basement Membrane Organization
Positive Regulation Of Wound Healing
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Signaling Receptor Activity
Negative Regulation Of Anoikis
Positive Regulation Of Protein Phosphorylation
Positive Regulation Of Endothelial Cell Proliferation
Vasculature Development
Lymph Vessel Development
Lymphangiogenesis
Sprouting Angiogenesis
Respiratory System Process
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Multicellular Organism Development
Positive Regulation Of Cell Proliferation
Positive Regulation Of Vascular Endothelial Growth Factor Production
Positive Regulation Of Endothelial Cell Migration
Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Kinase Activity
Cellular Response To Vascular Endothelial Growth Factor Stimulus
Vascular Endothelial Growth Factor Signaling Pathway
Negative Regulation Of Apoptotic Process
Positive Regulation Of MAPK Cascade
Positive Regulation Of JNK Cascade
Protein Autophosphorylation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Lung Alveolus Development
Blood Vessel Morphogenesis
Regulation Of Blood Vessel Remodeling
Positive Regulation Of ERK1 And ERK2 Cascade
Positive Regulation Of Protein Kinase C Signaling
Pathways
Elastic fibre formation
Fibronectin matrix formation
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Cell surface interactions at the vascular wall
Basigin interactions
Molecules associated with elastic fibres
Integrin cell surface interactions
Integrin cell surface interactions
Laminin interactions
Laminin interactions
Syndecan interactions
ECM proteoglycans
Other semaphorin interactions
Signal transduction by L1
Localization of the PINCH-ILK-PARVIN complex to focal adhesions
CHL1 interactions
RHO GTPases Activate Formins
Interleukin-4 and Interleukin-13 signaling
Platelet Adhesion to exposed collagen
MET activates PTK2 signaling
MET interacts with TNS proteins
HCMV Early Events
VEGF binds to VEGFR leading to receptor dimerization
NOTCH4 Intracellular Domain Regulates Transcription
Drugs
Antithymocyte immunoglobulin (rabbit)
Sorafenib
Sunitinib
Vatalanib
TG-100801
ABT-869
IMC-1C11
Pazopanib
Axitinib
Regorafenib
Lenvatinib
Nintedanib
Diseases
Lymphedemas, including: Lymphedema, hereditary I; Lymphedema-distichiasis syndrome (LD); Hypotrichosis-lymphedema-telangiectasia syndrome (HLTS)
GWAS
Depression (quantitative trait) (
20800221
)
Suicide in bipolar disorder (
25917933
)
Blood protein levels (
30072576
29875488
)
Serum folate levels (
29953918
)
Interacting Genes
78 interacting genes:
ACAP1
ACTN1
ACTN4
ARHGAP5
CANX
CD151
CD36
CD46
CD82
CD9
CRKL
DAG1
DOK1
EFNA4
EGFR
EPS8
FBLN1
FBXO2
FERMT1
FERMT2
FERMT3
FHL2
FLNA
FLNB
FLT4
FN1
HSPD1
HSPG2
ICAM4
IGF1R
ILK
ITGA1
ITGA10
ITGA11
ITGA2
ITGA3
ITGA4
ITGA5
ITGA6
ITGA8
ITGA9
ITGAV
ITGB1BP1
ITGB1BP2
LAMA1
LGALS1
LGALS3BP
LGALS8
MAP4K4
MET
NCKIPSD
NF2
NME1
NMRK2
PDHB
PIP5K1C
PLAUR
PRKCA
PRKCE
PTK2
PXN
RAB25
RACK1
SLC3A2
SPP1
TGFBR1
TGM2
TGOLN2
TIMP2
TLN1
TNC
TSPAN4
UPF2
VCAM1
VCAN
YWHAB
ZEB1
ZNF33A
16 interacting genes:
ATF7IP
DUSP19
ERBB2
GRB2
IKBKG
ITGA5
ITGB1
KDR
LRRK1
NEDD4
PTK2
PTPN11
SHC1
SHC3
VEGFC
VEGFD
Entrez ID
3688
2324
HPRD ID
00628
00636
Ensembl ID
ENSG00000150093
ENSG00000037280
Uniprot IDs
P05556
P35916
PDB IDs
1K11
1LHA
3G9W
3T9K
3VI3
3VI4
4DX9
4WJK
4WK0
4WK2
4WK4
4BSJ
4BSK
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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