ITGB1 and MAP4K4

Number of citations of the paper that reports this interaction (PubMedID 11967148)
37

Data Source:
HPRD (in vitro, in vivo)

		ITGB1	MAP4K4
Description		integrin subunit beta 1	mitogen-activated protein kinase kinase kinase kinase 4
Image
GO Annotations	Cellular Component	Ruffle Cell Cytoplasm Plasma Membrane Focal Adhesion Integrin Complex External Side Of Plasma Membrane Cell Surface Intercalated Disc Membrane Lamellipodium Filopodium Neuromuscular Junction Cleavage Furrow Ruffle Membrane Protein-containing Complex Integrin Alpha1-beta1 Complex Integrin Alpha2-beta1 Complex Integrin Alpha3-beta1 Complex Integrin Alpha5-beta1 Complex Integrin Alpha7-beta1 Complex Integrin Alpha8-beta1 Complex Integrin Alpha10-beta1 Complex Integrin Alpha11-beta1 Complex Myelin Sheath Abaxonal Region Sarcolemma Melanosome Dendritic Spine Receptor Complex Membrane Raft Perinuclear Region Of Cytoplasm Recycling Endosome Extracellular Exosome Invadopodium Membrane Glial Cell Projection Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Integral Component Of Synaptic Membrane	Cytoplasm Focal Adhesion
	Molecular Function	Virus Receptor Activity Fibronectin Binding Protease Binding Actin Binding Integrin Binding Protein Binding Coreceptor Activity C-X3-C Chemokine Binding Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding Protein Heterodimerization Activity Cell Adhesion Molecule Binding Collagen Binding Involved In Cell-matrix Adhesion Protein Tyrosine Kinase Binding	Creatine Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Establishment Of Mitotic Spindle Orientation In Utero Embryonic Development Cell Fate Specification Cell Migration Involved In Sprouting Angiogenesis Phagocytosis Cellular Defense Response Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Calcium-independent Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Cell Proliferation Germ Cell Migration Visual Learning Regulation Of Collagen Catabolic Process Positive Regulation Of Fibroblast Migration Cell Migration Cytokine-mediated Signaling Pathway Formation Of Radial Glial Scaffolds CD40 Signaling Pathway Cell Projection Organization Lamellipodium Assembly B Cell Differentiation Extracellular Matrix Organization Positive Regulation Of Cell Migration Cell-substrate Adhesion Receptor Internalization Cell Adhesion Mediated By Integrin Cell-cell Adhesion Mediated By Integrin Heterotypic Cell-cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Stress Fiber Assembly Positive Regulation Of GTPase Activity Sarcomere Organization Negative Regulation Of Cell Differentiation Positive Regulation Of Angiogenesis Viral Entry Into Host Cell Mesodermal Cell Differentiation Axon Extension Dendrite Morphogenesis Regulation Of Immune Response Modulation Of Chemical Synaptic Transmission Leukocyte Migration Leukocyte Tethering Or Rolling Regulation Of Cell Cycle Positive Regulation Of Protein Kinase B Signaling Cardiac Muscle Cell Differentiation Cellular Response To Low-density Lipoprotein Particle Stimulus Basement Membrane Organization Positive Regulation Of Wound Healing Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Signaling Receptor Activity Negative Regulation Of Anoikis	Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Microvillus Assembly Positive Regulation Of Cell Migration Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of ARF Protein Signal Transduction Activation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Disassembly
Pathways		Elastic fibre formation Fibronectin matrix formation Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Basigin interactions Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions ECM proteoglycans Other semaphorin interactions Signal transduction by L1 Localization of the PINCH-ILK-PARVIN complex to focal adhesions CHL1 interactions RHO GTPases Activate Formins Interleukin-4 and Interleukin-13 signaling Platelet Adhesion to exposed collagen MET activates PTK2 signaling MET interacts with TNS proteins HCMV Early Events	Oxidative Stress Induced Senescence
Drugs		Antithymocyte immunoglobulin (rabbit)
Diseases
GWAS		Depression (quantitative trait) ( 20800221) Suicide in bipolar disorder ( 25917933)	Alzheimer's disease ( 30636644) Asthma ( 31619474) Asthma (time to onset) ( 27130862) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		78 interacting genes: ACAP1 ACTN1 ACTN4 ARHGAP5 CANX CD151 CD36 CD46 CD82 CD9 CRKL DAG1 DOK1 EFNA4 EGFR EPS8 FBLN1 FBXO2 FERMT1 FERMT2 FERMT3 FHL2 FLNA FLNB FLT4 FN1 HSPD1 HSPG2 ICAM4 IGF1R ILK ITGA1 ITGA10 ITGA11 ITGA2 ITGA3 ITGA4 ITGA5 ITGA6 ITGA8 ITGA9 ITGAV ITGB1BP1 ITGB1BP2 LAMA1 LGALS1 LGALS3BP LGALS8 MAP4K4 MET NCKIPSD NF2 NME1 NMRK2 PDHB PIP5K1C PLAUR PRKCA PRKCE PTK2 PXN RAB25 RACK1 SLC3A2 SPP1 TGFBR1 TGM2 TGOLN2 TIMP2 TLN1 TNC TSPAN4 UPF2 VCAM1 VCAN YWHAB ZEB1 ZNF33A	18 interacting genes: BRCA1 CASP8 DOK1 GBP3 H2BC21 ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2
Entrez ID		3688	9448
HPRD ID		00628	05235
Ensembl ID		ENSG00000150093	ENSG00000071054
Uniprot IDs		P05556	B7Z3V5 O95819 V9HWH3
PDB IDs		1K11 1LHA 3G9W 3T9K 3VI3 3VI4 4DX9 4WJK 4WK0 4WK2 4WK4	4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q
Enriched GO Terms of Interacting Partners?
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