GRAP2 and LAX1

Number of citations of the paper that reports this interaction (PubMedID 12359715)
30

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		GRAP2	LAX1
Description		GRB2 related adaptor protein 2	lymphocyte transmembrane adaptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane	Golgi Apparatus Cytosol Plasma Membrane Membrane Integral Component Of Membrane Membrane Raft
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Protein Binding Protein Kinase Binding SH2 Domain Binding
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway	Inactivation Of MAPK Activity Adaptive Immune Response Immune Response Intracellular Signal Transduction B Cell Activation Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Negative Regulation Of T Cell Activation
Pathways		Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)	Male-pattern baldness ( 28196072)
Interacting Genes		66 interacting genes: BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MTUS2 PNMA1 PRPH2 RACK1 RBPMS RBX1 RIN3 RINT1 SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF526	9 interacting genes: GRAP2 GRB2 GRB7 IDH1 LCK NDN STAMBPL1 SYK ZAP70
Entrez ID		9402	54900
HPRD ID		05156	08312
Ensembl ID		ENSG00000100351	ENSG00000122188
Uniprot IDs		B7Z8E3 O75791 Q6FI14	Q8IWV1
PDB IDs		5GJH
Enriched GO Terms of Interacting Partners?
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