GRAP2 and GAREM1

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, two hybrid, affinity chromatography technology)

		GRAP2	GAREM1
Description		GRB2 related adaptor protein 2	GRB2 associated regulator of MAPK1 subtype 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane	Plasma Membrane
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Protein Binding Proline-rich Region Binding
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway	Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Cell Division Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Epidermal Growth Factor Stimulus
Pathways		Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation
Drugs
Diseases
GWAS		Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)	Breast cancer ( 29059683) Left ventricular internal dimension in diastole ( 29403010) Left ventricular internal dimension in systole ( 29403010)
Interacting Genes		66 interacting genes: BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MTUS2 PNMA1 PRPH2 RACK1 RBPMS RBX1 RIN3 RINT1 SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF526	4 interacting genes: CRK CRKL GRAP2 GRB2
Entrez ID		9402	64762
HPRD ID		05156	12685
Ensembl ID		ENSG00000100351	ENSG00000141441
Uniprot IDs		B7Z8E3 O75791 Q6FI14	Q9H706
PDB IDs		5GJH	2DKZ
Enriched GO Terms of Interacting Partners?
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