GRAP2 and GFAP

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		GRAP2	GFAP
Description		GRB2 related adaptor protein 2	glial fibrillary acidic protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane	Cytoplasm Lysosome Cytosol Intermediate Filament Intermediate Filament Cytoskeleton
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Identical Protein Binding
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway	Regulation Of Protein Complex Assembly Intermediate Filament Organization Regulation Of Chaperone-mediated Autophagy
Pathways		Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation	Nuclear signaling by ERBB4 Chaperone Mediated Autophagy
Drugs
Diseases			Alexander disease
GWAS		Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)	Asthma ( 31619474) Cognitive function ( 25644384) Craniofacial microsomia ( 26853712)
Interacting Genes		66 interacting genes: BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MTUS2 PNMA1 PRPH2 RACK1 RBPMS RBX1 RIN3 RINT1 SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF526	51 interacting genes: AKT1 APP AURKB BIRC2 CAMK2A CDK1 CEP76 CFAP206 CRYAB FAM50B GOLGA2 GRAP2 HGS IKBKG KIAA0408 KRT13 KRT15 KRT19 LGALS14 LMO2 MEN1 MOS MYO15B NEFL NXF1 PDLIM1 PDLIM7 PDZK1 PIAS2 PIH1D2 POM121 PRKACA PRKCA PRKCG PSEN1 PSEN2 RIBC2 ROCK1 RORA S100A1 S100B SH3YL1 SMARCB1 SRC STAT1 TLE5 TRIM27 TUBGCP4 UBE3A VIM ZC2HC1C
Entrez ID		9402	2670
HPRD ID		05156	00675
Ensembl ID		ENSG00000100351	ENSG00000131095
Uniprot IDs		B7Z8E3 O75791 Q6FI14	A7REI1 P14136
PDB IDs		5GJH	6A9P
Enriched GO Terms of Interacting Partners?
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