GRAP2 and CSF1R

Number of citations of the paper that reports this interaction (PubMedID 9857184)
24

Data Source:
HPRD (in vitro)

		GRAP2	CSF1R
Description		GRB2 related adaptor protein 2	colony stimulating factor 1 receptor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane	Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Intracellular Membrane-bounded Organelle Receptor Complex CSF1-CSF1R Complex
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Macrophage Colony-stimulating Factor Receptor Activity Protein Binding ATP Binding Growth Factor Binding Protein Phosphatase Binding Cytokine Binding Protein Homodimerization Activity
	Biological Process	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway	Positive Regulation Of Protein Phosphorylation Hematopoietic Progenitor Cell Differentiation Response To Ischemia Inflammatory Response Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Cell Proliferation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Regulation Of Cell Shape Peptidyl-tyrosine Phosphorylation Cytokine-mediated Signaling Pathway Olfactory Bulb Development Forebrain Neuron Differentiation Hemopoiesis Monocyte Differentiation Macrophage Differentiation Osteoclast Differentiation Positive Regulation Of Cell Migration Ruffle Organization Positive Regulation Of Kinase Activity Cellular Response To Macrophage Colony-stimulating Factor Stimulus Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Process Innate Immune Response Regulation Of Bone Resorption Cell-cell Junction Maintenance Phosphatidylinositol Metabolic Process Protein Autophosphorylation Phosphatidylinositol-mediated Signaling Mammary Gland Duct Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Microglial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Chemokine Secretion Positive Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization
Pathways		Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation	Other interleukin signaling Transcriptional Regulation by VENTX
Drugs			Imatinib Sunitinib ABT-869 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE
Diseases			Choriocarcinoma
GWAS		Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)	Blood protein levels ( 30072576 28240269) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252)
Interacting Genes		66 interacting genes: BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MTUS2 PNMA1 PRPH2 RACK1 RBPMS RBX1 RIN3 RINT1 SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF526	23 interacting genes: CBL CSF1 CTDSP1 CTDSP2 FYN GRAP2 GRB2 INPP5D INPPL1 KIT LAMC2 LYN PIK3CA PIK3R1 PIK3R2 RASA1 SHC1 SOCS1 SOCS3 SOS1 STAP2 THOC5 YES1
Entrez ID		9402	1436
HPRD ID		05156	01269
Ensembl ID		ENSG00000100351	ENSG00000182578
Uniprot IDs		B7Z8E3 O75791 Q6FI14	P07333
PDB IDs		5GJH	2I0V 2I0Y 2I1M 2OGV 3BEA 3DPK 3KRJ 3KRL 3LCD 3LCO 4DKD 4HW7 4LIQ 4R7H 4R7I 4WRL 4WRM 6IG8 6N33
Enriched GO Terms of Interacting Partners?
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