FBXO5 and EVI5

Number of citations of the paper that reports this interaction (PubMedID 16439210)
34

Data Source:
HPRD (in vivo)

		FBXO5	EVI5
Description		F-box protein 5	ecotropic viral integration site 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Spindle Cytosol Meiotic Spindle	Nucleus Microtubule Organizing Center Spindle Cytosol
	Molecular Function	Protein Binding Anaphase-promoting Complex Binding Protein Kinase Binding Metal Ion Binding Ubiquitin Ligase Inhibitor Activity	GTPase Activator Activity Protein Binding Rab GTPase Binding
	Biological Process	Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Oocyte Maturation Regulation Of DNA Replication Spindle Assembly Involved In Female Meiosis I Regulation Of Mitotic Nuclear Division Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Vesicle Organization Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Negative Regulation Of DNA Endoreduplication Positive Regulation Of Osteoblast Differentiation Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Mitotic Metaphase/anaphase Transition Microtubule Polymerization Cell Division Negative Regulation Of Ubiquitin-protein Transferase Activity Positive Regulation Of Biomineral Tissue Development Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Mesenchymal Stem Cell Migration Negative Regulation Of Cellular Senescence Negative Regulation Of Response To DNA Damage Stimulus	Intracellular Protein Transport Cell Cycle Retrograde Transport, Endosome To Golgi Positive Regulation Of GTPase Activity Cell Division Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		SCF-beta-TrCP mediated degradation of Emi1 Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Mitotic Metaphase/Anaphase Transition G1/S-Specific Transcription
Drugs
Diseases
GWAS		Body mass index ( 26426971) Chronotype ( 30696823) Morning person ( 30696823) Prostate cancer ( 23535732)	Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma or allergic disease (pleiotropy) ( 29785011) Cholesterol, total ( 24097068 25961943 20686565) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) LDL cholesterol ( 30275531 25961943) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602 19525955 21833088 27386562) Systemic lupus erythematosus ( 28714469) Total cholesterol levels ( 28334899 30275531)
Interacting Genes		16 interacting genes: ANAPC1 ANAPC11 ANAPC2 ANAPC5 ANAPC7 CDC16 CDC20 CDC23 CDK1 EVI5 FZR1 SKP1 SRC TPM3 UBE2C UBE2S	5 interacting genes: AURKB BIRC5 FBXO5 INCENP STX3
Entrez ID		26271	7813
HPRD ID		09348	04249
Ensembl ID		ENSG00000112029	ENSG00000067208
Uniprot IDs		Q9UKT4	O60447 Q59FE7
PDB IDs		2M6N 4UI9
Enriched GO Terms of Interacting Partners?
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