GFAP and PSEN2

Number of citations of the paper that reports this interaction (PubMedID 12058025)
19

Data Source:
BioGRID (two hybrid)

		GFAP	PSEN2
Description		glial fibrillary acidic protein	presenilin 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Lysosome Cytosol Intermediate Filament Intermediate Filament Cytoskeleton	Golgi Membrane Kinetochore Nucleus Nuclear Inner Membrane Mitochondrial Inner Membrane Lysosomal Membrane Early Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Centrosome Plasma Membrane Integral Component Of Plasma Membrane Cell Cortex Synaptic Vesicle Cell Surface Membrane Apical Plasma Membrane Z Disc Axon Growth Cone Neuromuscular Junction Protein-containing Complex Ciliary Rootlet Neuronal Cell Body Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Integral Component Of Presynaptic Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Identical Protein Binding	Endopeptidase Activity Protein Binding Aspartic Endopeptidase Activity, Intramembrane Cleaving
	Biological Process	Regulation Of Protein Complex Assembly Intermediate Filament Organization Regulation Of Chaperone-mediated Autophagy	Response To Hypoxia Membrane Protein Ectodomain Proteolysis Calcium Ion Transport Notch Receptor Processing Protein Processing Membrane Protein Intracellular Domain Proteolysis Notch Receptor Processing, Ligand-dependent Intracellular Signal Transduction Amyloid Precursor Protein Catabolic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity Ephrin Receptor Signaling Pathway Amyloid-beta Metabolic Process Regulation Of Calcium Import Into The Mitochondrion Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways		Nuclear signaling by ERBB4 Chaperone Mediated Autophagy	Nuclear signaling by ERBB4 Regulated proteolysis of p75NTR NRIF signals cell death from the nucleus Activated NOTCH1 Transmits Signal to the Nucleus Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants NOTCH2 Activation and Transmission of Signal to the Nucleus EPH-ephrin mediated repulsion of cells NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH4 Activation and Transmission of Signal to the Nucleus Noncanonical activation of NOTCH3
Drugs
Diseases		Alexander disease	Alzheimer's disease (AD)
GWAS		Asthma ( 31619474) Cognitive function ( 25644384) Craniofacial microsomia ( 26853712)	Heel bone mineral density ( 30598549)
Interacting Genes		51 interacting genes: AKT1 APP AURKB BIRC2 CAMK2A CDK1 CEP76 CFAP206 CRYAB FAM50B GOLGA2 GRAP2 HGS IKBKG KIAA0408 KRT13 KRT15 KRT19 LGALS14 LMO2 MEN1 MOS MYO15B NEFL NXF1 PDLIM1 PDLIM7 PDZK1 PIAS2 PIH1D2 POM121 PRKACA PRKCA PRKCG PSEN1 PSEN2 RIBC2 ROCK1 RORA S100A1 S100B SH3YL1 SMARCB1 SRC STAT1 TLE5 TRIM27 TUBGCP4 UBE3A VIM ZC2HC1C	61 interacting genes: AAMP ACTG1 AP1G1 APH1A APH1B APP AURKA BCL2L1 CAPN1 CASP1 CASP3 CASP6 CASP7 CASP8 CEP55 CFLAR CHKA CIB1 CSNK1A1 CSNK1D CSNK2A1 CTNNB1 CTNND2 DNAJB1 DOCK3 ECD EID1 ELAVL1 EVI5L EXOC6 FBXL12 FHL2 FLNA FLNB GCDH GFAP HLA-DMB HPS1 ICAM5 IFIT3 IFIT5 KCNIP3 KCNIP4 LIPF MAST1 METTL2B NCSTN NOS3 NOTCH1 NOTCH2 NOTCH3 NOTCH4 OGA PDCD4 PSENEN RAB11A RHEB RNF32 SPC24 SRI UBQLN1
Entrez ID		2670	5664
HPRD ID		00675	02860
Ensembl ID		ENSG00000131095	ENSG00000143801
Uniprot IDs		A7REI1 P14136	P49810
PDB IDs		6A9P
Enriched GO Terms of Interacting Partners?
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