FRMD6 and HMBOX1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FRMD6	HMBOX1
Description		FERM domain containing 6	homeobox containing 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Apical Junction Complex	Nuclear Chromosome, Telomeric Region Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cajal Body Nuclear Body PML Body
	Molecular Function	Protein Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Double-stranded Telomeric DNA Binding Protein Binding Telomeric DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding
	Biological Process	Apical Constriction Actomyosin Structure Organization Regulation Of Actin Filament-based Process Cellular Protein Localization	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Telomerase Activity Positive Regulation Of Telomerase Activity
Pathways
Drugs
Diseases
GWAS		Anticoagulant levels ( 22216198) Brain structure ( 20171287) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal atrophy ( 19668339) Lung cancer (smoking interaction) ( 24658283) Multiple sclerosis ( 31604244) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Total ventricular volume ( 21116278) Triglyceride levels x loop diuretics use interaction ( 31806883)	Obesity-related traits ( 23251661)
Interacting Genes		20 interacting genes: - BLZF1 COX6B2 DNAJA3 EXOC5 GMCL1 HMBOX1 IKZF1 JMJD6 LZTS2 MED4 MID2 MLH1 RASSF8 SSX2IP SUV39H1 TCF12 TSC22D4 WDR7 YWHAB	49 interacting genes: ABITRAM AEBP2 APP ATP5PO BYSL C8orf33 CARD9 CBX8 CCNG1 DAB1 DYNLL2 ENTPD2 FAM13C FAM161A FAM74A4 FARS2 FNDC11 FRMD6 FXR2 KAT5 LNX1 MAGEH1 MFAP1 MORF4L1 MRPL11 MRPL28 PIP4K2B PKD1P1 PRKAA1 PRKAA2 RBMY2FP REEP6 RPL9 SAP30L SFR1 SH2D4A SNRPB2 TCEANC UBA6 UBE2Z VPS72 WT1 ZBTB24 ZMAT2 ZNF337 ZNF417 ZNF581 ZNF587 ZNF688
Entrez ID		122786	79618
HPRD ID		12646	07964
Ensembl ID		ENSG00000139926	ENSG00000147421
Uniprot IDs		Q96NE9	D3DSU2 Q6NT76
PDB IDs			2CUF 4J19
Enriched GO Terms of Interacting Partners?
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