HMBOX1 and AEBP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		HMBOX1	AEBP2
Description		homeobox containing 1	AE binding protein 2
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GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cajal Body Nuclear Body PML Body	Nuclear Chromatin Nucleoplasm ESC/E(Z) Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Double-stranded Telomeric DNA Binding Protein Binding Telomeric DNA Binding Identical Protein Binding Sequence-specific DNA Binding Protein-containing Complex Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Transcription Corepressor Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Chromatin Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Regulation Of Telomerase Activity Positive Regulation Of Telomerase Activity	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Negative Regulation Of Gene Expression, Epigenetic
Pathways			PRC2 methylates histones and DNA PKMTs methylate histone lysines
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Chronic mountain sickness ( 31417607) Diastolic blood pressure ( 30224653) Diverticular disease ( 30177863) Height ( 28552196) Lung function (FEV1/FVC) ( 30804560) Manganese levels ( 26025379) Obesity-related traits ( 23251661) Pulmonary function ( 21946350) Response to fenofibrate (LDL cholesterol levels) ( 27002377)
Interacting Genes		49 interacting genes: ABITRAM AEBP2 APP ATP5PO BYSL C8orf33 CARD9 CBX8 CCNG1 DAB1 DYNLL2 ENTPD2 FAM13C FAM161A FAM74A4 FARS2 FNDC11 FRMD6 FXR2 KAT5 LNX1 MAGEH1 MFAP1 MORF4L1 MRPL11 MRPL28 PIP4K2B PKD1P1 PRKAA1 PRKAA2 RBMY2FP REEP6 RPL9 SAP30L SFR1 SH2D4A SNRPB2 TCEANC UBA6 UBE2Z VPS72 WT1 ZBTB24 ZMAT2 ZNF337 ZNF417 ZNF581 ZNF587 ZNF688	11 interacting genes: APP EED H1-1 H1-2 HMBOX1 JMJD6 LDOC1 RALYL RBBP4 SUZ12 THAP1
Entrez ID		79618	121536
HPRD ID		07964	16477
Ensembl ID		ENSG00000147421	ENSG00000139154
Uniprot IDs		D3DSU2 Q6NT76	Q6ZN18
PDB IDs		2CUF 4J19	5WAI 5Y0U 5Y1U 6C23 6C24
Enriched GO Terms of Interacting Partners?
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