FRMD6 and EXOC5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		FRMD6	EXOC5
Description		FERM domain containing 6	exocyst complex component 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Plasma Membrane Apical Junction Complex	Exocyst Cytoplasm Cytosol Midbody
	Molecular Function	Protein Binding	Protein Binding Ral GTPase Binding Protein N-terminus Binding
	Biological Process	Apical Constriction Actomyosin Structure Organization Regulation Of Actin Filament-based Process Cellular Protein Localization	Establishment Of Planar Polarity Exocytosis Post-Golgi Vesicle-mediated Transport Golgi To Plasma Membrane Transport Protein Transport Vesicle Docking Protein Localization To Plasma Membrane Epithelial Cell Apoptotic Process Non-motile Cilium Assembly
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Insulin processing VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Anticoagulant levels ( 22216198) Brain structure ( 20171287) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal atrophy ( 19668339) Lung cancer (smoking interaction) ( 24658283) Multiple sclerosis ( 31604244) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Total ventricular volume ( 21116278) Triglyceride levels x loop diuretics use interaction ( 31806883)	Alcohol consumption ( 23743675) Chronotype ( 30696823) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556)
Interacting Genes		20 interacting genes: - BLZF1 COX6B2 DNAJA3 EXOC5 GMCL1 HMBOX1 IKZF1 JMJD6 LZTS2 MED4 MID2 MLH1 RASSF8 SSX2IP SUV39H1 TCF12 TSC22D4 WDR7 YWHAB	34 interacting genes: ACTR3B ADCK1 ARF6 BARD1 BRMS1L CCDC102B CDH2 DEUP1 DNAAF4 EDRF1 ENO2 FRMD6 GNB1 HDDC3 HGS ICA1 KXD1 MAGEA6 OAS1 PRKCG PSTPIP1 PTK6 PYCARD RAB14 RAB4A RAB4B RALA SOX10 SPACA9 TBX21 TNPO2 TTC23L TXLNB TXNL4A
Entrez ID		122786	10640
HPRD ID		12646	07258
Ensembl ID		ENSG00000139926	ENSG00000070367
Uniprot IDs		Q96NE9	O00471
PDB IDs
Enriched GO Terms of Interacting Partners?
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