CKM and CBLC

Number of citations of the paper that reports this interaction (PubMedID 20525694)
23

Data Source:
BioGRID (enzymatic study)

		CKM	CBLC
Description		creatine kinase, M-type	Cbl proto-oncogene C
Image
GO Annotations	Cellular Component	Extracellular Space Cytosol	Plasma Membrane Membrane Raft
	Molecular Function	Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Zinc Ion Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Activity
	Biological Process	Creatine Metabolic Process Phosphorylation Phosphocreatine Biosynthetic Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity
Pathways		Creatine metabolism
Drugs		Creatine (Diaminomethyl-Methyl-Amino)-Acetic Acid D-Arginine Phosphocreatine
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Creatine kinase in statin users ( 25214527) Intelligence (MTAG) ( 29326435)	Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 24507774) Weight ( 28552196)
Interacting Genes		11 interacting genes: CBLC CKB FHL2 HSPB2 MYOC MYOM2 NOS1AP TRIM54 TRIM55 TRIM63 YWHAQ	53 interacting genes: AKT1 BAP1 BIRC2 CCND2 CDK6 CDKN2B CHFR CKM CRK EGFR EPHA2 ERBB2 FGFR4 FYN GLIS2 GRB2 ITCH LATS2 LYN MAP2K3 MDM4 MYC NACAD NF2 NFIC NSD3 OTUD6A OXA1L RAF1 SH3GL3 SHC1 SPRY2 SRC STK11 TERT TGFB1I1 TP53 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 ZAP70
Entrez ID		1158	23624
HPRD ID		00426	09765
Ensembl ID		ENSG00000104879	ENSG00000142273
Uniprot IDs		B2R892 P06732	Q9ULV8
PDB IDs		1I0E	3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR
Enriched GO Terms of Interacting Partners?
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