CBLC and GLIS2

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CBLC	GLIS2
Description		Cbl proto-oncogene C	GLIS family zinc finger 2
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Raft	Nucleus Cytoplasm Nuclear Speck Non-motile Cilium
	Molecular Function	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Zinc Ion Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Smoothened Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription From RNA Polymerase II Promoter Involved In Kidney Development Cell Differentiation Involved In Kidney Development Positive Regulation Of Protein Localization To Nucleus
Pathways
Drugs
Diseases			Nephronophthisis-medullary cystic kidney disease, including; Nephronophthisis (NPH) ; Nephronophthisis-like nephropathy 1; Medullary cystic kidney disease 1; Medullary cystic kidney disease 2 (MSKD2)
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 24507774) Weight ( 28552196)	Erectile dysfunction ( 30583798) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 26635082) Prostate-specific antigen levels ( 28139693)
Interacting Genes		53 interacting genes: AKT1 BAP1 BIRC2 CCND2 CDK6 CDKN2B CHFR CKM CRK EGFR EPHA2 ERBB2 FGFR4 FYN GLIS2 GRB2 ITCH LATS2 LYN MAP2K3 MDM4 MYC NACAD NF2 NFIC NSD3 OTUD6A OXA1L RAF1 SH3GL3 SHC1 SPRY2 SRC STK11 TERT TGFB1I1 TP53 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 ZAP70	49 interacting genes: AKT1 ARAF ARNT BCAR1 BECN1 CBLC CCND2 CCNE1 CD44 CDK4 CDK6 CDKN2A CDKN2B CPSF1 CTNNB1 EPHA2 ERBB2 FGFR4 FZR1 GLIS1 GPSM2 HGF HIF1A LATS2 MAP2K3 MAP2K5 MAP2K6 MAP3K5 MDM2 MDM4 MET MYC NF2 NFIC NSD3 PIK3CA RAF1 RASSF1 RBFOX2 SOX3 SPECC1L STK11 TEAD2 TERT TRIM32 U2AF2 WNK1 WT1 XAB2
Entrez ID		23624	84662
HPRD ID		09765	12256
Ensembl ID		ENSG00000142273	ENSG00000126603
Uniprot IDs		Q9ULV8	B3KTH4 Q9BZE0
PDB IDs		3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?