CKM and TRIM63

Number of citations of the paper that reports this interaction (PubMedID 18222470)
48

Data Source:
HPRD (in vivo)

		CKM	TRIM63
Description		creatine kinase, M-type	tripartite motif containing 63
Image
GO Annotations	Cellular Component	Extracellular Space Cytosol	Nucleus Cytoplasm Microtubule Z Disc M Band
	Molecular Function	Creatine Kinase Activity Protein Binding ATP Binding Kinase Activity	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Titin Binding
	Biological Process	Creatine Metabolic Process Phosphorylation Phosphocreatine Biosynthetic Process	Muscle Contraction Signal Transduction Negative Regulation Of Cardiac Muscle Hypertrophy Skeletal Muscle Atrophy Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Response To Glucocorticoid Response To Interleukin-1
Pathways		Creatine metabolism	FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Creatine (Diaminomethyl-Methyl-Amino)-Acetic Acid D-Arginine Phosphocreatine
Diseases
GWAS		Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Creatine kinase in statin users ( 25214527) Intelligence (MTAG) ( 29326435)
Interacting Genes		11 interacting genes: CBLC CKB FHL2 HSPB2 MYOC MYOM2 NOS1AP TRIM54 TRIM55 TRIM63 YWHAQ	93 interacting genes: ACTA1 AK1 AKR7A2 ALDOA ANKRD1 APP ATP5F1B ATXN3 ATXN3L BAP1 CKB CKM DCAF6 DES EEF1G EHHADH EIF3E ENO3 ESPL1 FHL2 FLNC GFM1 GMEB1 HIBADH HSPD1 JOSD1 LMCD1 MRPL19 MRPL41 MYBPC1 MYBPC3 MYH6 MYL2 MYOT MYOZ1 NDUFA1 NEB NEBL NOMO1 NRAP OTUB1 OTUB2 PDHB PDK4 PIAS1 PIAS2 PIAS3 PKM PSMD4 PYGM SENP2 SENP3 SQSTM1 SRF STAM SUMO2 TCAP THRA TNNC1 TNNI1 TNNI2 TNNI3 TNNT1 TNNT3 TRIM54 TRIM55 TTN UBE2D1 UBE2D2 UBE2D3 UBE2E3 UBE2I UBE2J1 UBE2K UBE2N UBE2U UBE2V2 UCHL1 UCHL3 UCHL5 UQCRC1 USP13 USP15 USP2 USP21 USP28 USP33 USP4 USP5 USP7 USP8 UXT YOD1
Entrez ID		1158	84676
HPRD ID		00426	05843
Ensembl ID		ENSG00000104879	ENSG00000158022
Uniprot IDs		B2R892 P06732	Q969Q1
PDB IDs		1I0E	2D8U 3DDT 4M3L
Enriched GO Terms of Interacting Partners?
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