CBLC and TGFB1I1

Number of citations of the paper that reports this interaction (PubMedID 24831009)
19

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		CBLC	TGFB1I1
Description		Cbl proto-oncogene C	transforming growth factor beta 1 induced transcript 1
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Raft	Cytosol Cytoskeleton Plasma Membrane Focal Adhesion Nuclear Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Zinc Ion Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Metal Ion Binding Roundabout Binding Androgen Receptor Binding I-SMAD Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity	Transcription By RNA Polymerase II Cell Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Cell Proliferation Response To Heat Positive Regulation Of Epithelial To Mesenchymal Transition Wnt Signaling Pathway Morphogenesis Of Embryonic Epithelium Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Androgen Receptor Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Epithelial Cell Differentiation Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways
Drugs
Diseases
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 24507774) Weight ( 28552196)	Metabolite levels ( 23823483)
Interacting Genes		53 interacting genes: AKT1 BAP1 BIRC2 CCND2 CDK6 CDKN2B CHFR CKM CRK EGFR EPHA2 ERBB2 FGFR4 FYN GLIS2 GRB2 ITCH LATS2 LYN MAP2K3 MDM4 MYC NACAD NF2 NFIC NSD3 OTUD6A OXA1L RAF1 SH3GL3 SHC1 SPRY2 SRC STK11 TERT TGFB1I1 TP53 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 ZAP70	29 interacting genes: AR CBLB CBLC CDKN2B CRKL CSK EP300 FKBP1A GIT1 GIT2 GP1BB HIPK3 HSPB1 ITGA4 MAPK15 NEDD4L NR3C1 PLA2G3 PTK2 PTK2B PTPN12 SDC4 SLC6A3 SMAD7 SVIL TGFBR2 TRAF4 UBQLN4 VCL
Entrez ID		23624	7041
HPRD ID		09765	03831
Ensembl ID		ENSG00000142273	ENSG00000140682
Uniprot IDs		Q9ULV8	A0A024QZE7 O43294
PDB IDs		3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR
Enriched GO Terms of Interacting Partners?
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