CBLC and TRIM46

Number of citations of the paper that reports this interaction (PubMedID 22493164)
5

Data Source:
BioGRID (two hybrid)

		CBLC	TRIM46
Description		Cbl proto-oncogene C	tripartite motif containing 46
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Raft	Cytoskeleton Axon Initial Segment Main Axon Axon Cytoplasm Proximal Neuron Projection
	Molecular Function	Phosphotyrosine Residue Binding Epidermal Growth Factor Receptor Binding Calcium Ion Binding Zinc Ion Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding Ubiquitin Protein Ligase Activity	Zinc Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Signal Transduction Cell Surface Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity	Microtubule Bundle Formation Neuron Migration Axonogenesis Negative Regulation Of Axon Extension Anterograde Synaptic Vesicle Transport Protein Localization To Axon Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Cellular Protein Localization
Pathways			Interferon gamma signaling
Drugs
Diseases
GWAS		Alzheimer's disease (onset between ages 58 and 79) ( 30979435) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Alzheimer's disease or HDL levels (pleiotropy) ( 30805717) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x age interaction ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) LDL cholesterol ( 24507774) Weight ( 28552196)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Breast cancer ( 29059683) Crohn's disease ( 28067908) Estimated glomerular filtration rate ( 31152163) Inflammatory bowel disease ( 28067908) Microalbuminuria ( 31511532) Serum uric acid levels ( 30993211) Urate levels ( 31578528 23263486) Urinary albumin-to-creatinine ratio ( 31511532) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737)
Interacting Genes		53 interacting genes: AKT1 BAP1 BIRC2 CCND2 CDK6 CDKN2B CHFR CKM CRK EGFR EPHA2 ERBB2 FGFR4 FYN GLIS2 GRB2 ITCH LATS2 LYN MAP2K3 MDM4 MYC NACAD NF2 NFIC NSD3 OTUD6A OXA1L RAF1 SH3GL3 SHC1 SPRY2 SRC STK11 TERT TGFB1I1 TP53 TRAF4 TRIM46 TRIP6 UBC UBE2D1 UBE2D2 UBE2D3 UBE2H UBE2I UBE2K UBE2L3 UBE2L6 UBE2R2 USP2 USP21 ZAP70	20 interacting genes: AK5 APP BRCA1 CBLC MDM4 MTNR1B OTUD6A RNF125 RNF7 TK1 TRIM9 TSG101 UBE2D2 UBE2U UBE2Z UCHL5 USP1 USP15 USP2 USP32
Entrez ID		23624	80128
HPRD ID		09765	15563
Ensembl ID		ENSG00000142273	ENSG00000163462
Uniprot IDs		Q9ULV8	A0A087WUH1 B7Z4F9 F5GYK0 Q7Z4K8
PDB IDs		3OP0 3VRN 3VRO 3VRP 3VRQ 3VRR
Enriched GO Terms of Interacting Partners?
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