FASLG and SH3GL3

Number of citations of the paper that reports this interaction (PMID 19807924)
2

Data Source:
BioGRID (unspecified method)

		FASLG	SH3GL3
Gene Name		Fas ligand (TNF superfamily, member 6)	SH3-domain GRB2-like 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Membrane-bounded Vesicle Lumen Extracellular Vesicular Exosome	Early Endosome Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Endocytosis Signal Transduction Central Nervous System Development
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)	Height ( 18391950 18391951 20397748)
Protein-Protein Interactions		74 interactors: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NL OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1	44 interactors: ADRB1 AES ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNM1 DPPA4 DPYSL4 EGFL6 EMD FAM173A FASLG GABBR2 HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RBM48 RER1 RPL35A SEPT8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TNNT1 TOE1 VIM WASL WDR33
Entrez ID		356	6457
HPRD ID		00610	04528
Ensembl ID		ENSG00000117560	ENSG00000140600
Uniprot IDs		P48023 Q53ZZ1	Q99963
PDB IDs		1BZI	2EW3 2Z0V
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune System Process Regulation Of Immune System Process Regulation Of Cell Activation Endocytosis Positive Regulation Of Cell Activation Immune Response Regulation Of Cellular Process T Cell Receptor Signaling Pathway Axon Guidance Regulation Of Lymphocyte Activation Signal Transduction Locomotion Positive Regulation Of T Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Defense Response Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-cell Adhesion Signaling Regulation Of Signal Transduction Cell Communication Chemotaxis T Cell Costimulation Axonogenesis Response To External Stimulus Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Axon Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Vesicle-mediated Transport Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway	Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signaling Regulation Of ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Signaling Signal Transduction Vesicle-mediated Transport Cell Communication Movement Of Cell Or Subcellular Component Regulation Of Vesicle-mediated Transport Response To Stimulus Cellular Response To Stimulus Cell Death Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Membrane Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process System Development Neuron Development Apoptotic Process Cellular Process Generation Of Neurons Actin Filament-based Movement Multicellular Organismal Development Nervous System Development Programmed Cell Death Regulation Of Signaling Neurogenesis Regulation Of Endocytosis Regulation Of Signal Transduction Negative Regulation Of Neuron Differentiation Neuron Projection Development Establishment Of Vesicle Localization Synaptic Transmission Positive Regulation Of Apoptotic Process Cell Projection Morphogenesis Neuron Differentiation Vesicle Localization Response To Growth Factor Axon Guidance Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish
Tagcloud (Intersection) ?