FASLG and TJP3

Number of citations of the paper that reports this interaction (PMID 19807924)
2

Data Source:
BioGRID (unspecified method)

		FASLG	TJP3
Gene Name		Fas ligand (TNF superfamily, member 6)	tight junction protein 3
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Membrane-bounded Vesicle Lumen Extracellular Vesicular Exosome	Nucleus Nucleoplasm Tight Junction Apical Plasma Membrane Cell Junction
	Molecular Function	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)
Protein-Protein Interactions		74 interactors: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NL OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1	5 interactors: CLDN1 FASLG GJC1 INADL TJP1
Entrez ID		356	27134
HPRD ID		00610	18194
Ensembl ID		ENSG00000117560	ENSG00000105289
Uniprot IDs		P48023 Q53ZZ1	B3KR73 F5H2X0 O95049
PDB IDs		1BZI	3KFV
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune System Process Regulation Of Immune System Process Regulation Of Cell Activation Endocytosis Positive Regulation Of Cell Activation Immune Response Regulation Of Cellular Process T Cell Receptor Signaling Pathway Axon Guidance Regulation Of Lymphocyte Activation Signal Transduction Locomotion Positive Regulation Of T Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Defense Response Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-cell Adhesion Signaling Regulation Of Signal Transduction Cell Communication Chemotaxis T Cell Costimulation Axonogenesis Response To External Stimulus Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Axon Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Vesicle-mediated Transport Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway	Cell-cell Junction Organization Cell-cell Junction Assembly Cell Junction Assembly Cell-cell Signaling Involved In Cell-cell Junction Organization Response To Glucose Chemical Homeostasis Cell-cell Signaling Endosomal Lumen Acidification Response To Carbohydrate Response To Magnetism Retinal Cell Programmed Cell Death Necroptotic Signaling Pathway Establishment Of Endothelial Intestinal Barrier Response To Lipopolysaccharide Cellular Chloride Ion Homeostasis Inflammatory Cell Apoptotic Process Homeostatic Process Atrial Cardiac Muscle Cell To AV Node Cell Communication Atrial Cardiac Muscle Cell Action Potential Chloride Ion Homeostasis Response To Molecule Of Bacterial Origin Positive Regulation Of Endothelial Cell Apoptotic Process Negative Regulation Of Vascular Permeability Cell-cell Signaling Involved In Cardiac Conduction Establishment Of Skin Barrier T Cell Apoptotic Process Cell Development Response To Bacterium Regulation Of Water Loss Via Skin Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Intracellular PH Reduction Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Cellular Component Assembly PH Reduction Cellular Chemical Homeostasis Gap Junction Assembly Positive Regulation Of ERBB Signaling Pathway Establishment Of Endothelial Barrier Cardiac Muscle Cell Action Potential Involved In Contraction Hippo Signaling Endosome Organization Necroptotic Process Regulation Of Vascular Permeability Multicellular Organismal Development Regulation Of Endothelial Cell Apoptotic Process Anatomical Structure Development Cardiac Muscle Cell Action Potential Cellular Homeostasis Blastocyst Formation Developmental Programmed Cell Death
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	adherens atp1a1 atp1b1 bbs1 biogenesis cdh1 cilium cldn2 delineation dynamic fasn foxo1 glycolytic hif1a invaluable junction maturation matured metabolomic monolayer nutrient profound proliferating tight transam transcriptomic tubule uncovered utilizing
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	adherens atp1a1 atp1b1 bbs1 biogenesis cdh1 cilium cldn2 delineation dynamic fasn foxo1 glycolytic hif1a invaluable junction maturation matured metabolomic monolayer nutrient profound proliferating tight transam transcriptomic tubule uncovered utilizing
Tagcloud (Intersection) ?