SH3GL3 and SH3GL2

Number of citations of the paper that reports this interaction (PMID 16115810)
21

Data Source:
HPRD (two hybrid, in vivo)

		SH3GL3	SH3GL2
Gene Name		SH3-domain GRB2-like 3	SH3-domain GRB2-like 2
Image
Gene Ontology Annotations	Cellular Component	Early Endosome Membrane Extracellular Vesicular Exosome	Golgi Membrane Cytosol Plasma Membrane Clathrin-coated Endocytic Vesicle Membrane Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Protein Binding Lipid Binding Identical Protein Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development	Regulation Of Receptor Internalization Post-Golgi Vesicle-mediated Transport Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Central Nervous System Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Synaptic Vesicle Endocytosis Membrane Organization
Pathways			Retrograde neurotrophin signalling EGFR downregulation Signalling by NGF Axon guidance Golgi Associated Vesicle Biogenesis L1CAM interactions Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by EGFRvIII in Cancer Recycling pathway of L1 Clathrin derived vesicle budding Lysosome Vesicle Biogenesis Signaling by EGFR MHC class II antigen presentation Signaling by EGFR in Cancer trans-Golgi Network Vesicle Budding Adaptive Immune System
Drugs
Diseases
GWAS		Height ( 18391950 18391951 20397748)	Cognitive performance ( 19734545) Heart failure ( 20445134) Multiple sclerosis ( 19010793) Obesity-related traits ( 23251661) Parkinson's disease ( 22451204)
Protein-Protein Interactions		44 interactors: ADRB1 AES ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNM1 DPPA4 DPYSL4 EGFL6 EMD FAM173A FASLG GABBR2 HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RBM48 RER1 RPL35A SEPT8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TNNT1 TOE1 VIM WASL WDR33	53 interactors: ACTG1 ADAM15 ADAM19 ADRB1 AMPH APP ARNT2 ATXN2 BIN1 CD2AP CLEC3B DACT1 DLGAP4 DNM1 DNM2 DPPA4 DPYSL4 EGFL6 EMD ERH F13A1 GCH1 GSTM3 HLA-DQA1 IGHM IL6 ITCH ITSN1 LCP2 LRRK2 MAP4K3 MAST2 PAK2 PAXIP1 PDCD6IP PPP1R21 PPP6R1 PRR14 SH3GL1 SH3GL3 SH3KBP1 SLC17A7 SYN1 SYNJ1 SYNJ2 TCEA2 TERF1 TIAM2 TMEM108 TYMS ZNF219 ZNF580 ZXDC
Entrez ID		6457	6456
HPRD ID		04528	05125
Ensembl ID		ENSG00000140600	ENSG00000107295
Uniprot IDs		Q99963	B7Z7W3 F5H5J3 Q7Z376 Q8IZ09 Q99962
PDB IDs		2EW3 2Z0V	1X03 1X04 2D4C 2DBM
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signaling Regulation Of ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Signaling Signal Transduction Vesicle-mediated Transport Cell Communication Movement Of Cell Or Subcellular Component Regulation Of Vesicle-mediated Transport Response To Stimulus Cellular Response To Stimulus Cell Death Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Membrane Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process System Development Neuron Development Apoptotic Process Cellular Process Generation Of Neurons Actin Filament-based Movement Multicellular Organismal Development Nervous System Development Programmed Cell Death Regulation Of Signaling Neurogenesis Regulation Of Endocytosis Regulation Of Signal Transduction Negative Regulation Of Neuron Differentiation Neuron Projection Development Establishment Of Vesicle Localization Synaptic Transmission Positive Regulation Of Apoptotic Process Cell Projection Morphogenesis Neuron Differentiation Vesicle Localization Response To Growth Factor Axon Guidance Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis	Endocytosis Developmental Process Neuron Projection Morphogenesis Neuron Projection Development Vesicle-mediated Transport Signaling Locomotion Cell Communication Cell Differentiation Cell-cell Signaling System Development Cell Projection Organization Positive Regulation Of Programmed Cell Death Neuron Development Positive Regulation Of Cell Death Response To Stimulus Cell Projection Morphogenesis Multicellular Organismal Development Cell Morphogenesis Cell Part Morphogenesis Nervous System Development Cell Development Neuron Differentiation Synaptic Transmission Positive Regulation Of Apoptotic Process Regulation Of Cellular Component Organization Chemotaxis Innate Immune Response Anatomical Structure Development Cell Death Platelet Activation Death Synaptic Vesicle Endocytosis Synaptic Vesicle Recycling Generation Of Neurons Response To External Stimulus Defense Response Synaptic Vesicle Transport Secretion By Cell Cellular Response To Stimulus Regulation Of Synaptic Vesicle Transport Positive Regulation Of Metabolic Process Cell Morphogenesis Involved In Differentiation Neurogenesis Regulation Of Vesicle-mediated Transport Response To Stress Signal Transduction Axon Guidance Apoptotic Process Regulation Of Apoptotic Process
Tagcloud ?		85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish	250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Difference) ?		85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish	250k 9p22 affymetrix alteration array biopsies corresponding deleted evident forced heterozygosity informative interactor internalization invasion modulating mucosal nsclc nspi paired platform scanning ser ss transfected tyr understand usp9x validation
Tagcloud (Intersection) ?