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FASLG and SH3RF2
Number of citations of the paper that reports this interaction (PMID
19807924
)
2
Data Source:
BioGRID
(unspecified method)
FASLG
SH3RF2
Gene Name
Fas ligand (TNF superfamily, member 6)
SH3 domain containing ring finger 2
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Extracellular Region
Extracellular Space
Nucleus
Plasma Membrane
Integral Component Of Plasma Membrane
Caveola
External Side Of Plasma Membrane
Lysosomal Lumen
Perinuclear Region Of Cytoplasm
Cytoplasmic Membrane-bounded Vesicle Lumen
Extracellular Vesicular Exosome
Nucleoplasm
Molecular Function
Receptor Binding
Death Receptor Binding
Cytokine Activity
Tumor Necrosis Factor Receptor Binding
Protein Binding
Protein Phosphatase Inhibitor Activity
Protein Binding
Protein Phosphatase 1 Binding
Zinc Ion Binding
Ligase Activity
Phosphatase Binding
Biological Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Transcription, DNA-templated
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Cell Apoptotic Process
Immune Response
Signal Transduction
Cell-cell Signaling
Positive Regulation Of Cell Proliferation
Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Negative Regulation Of Angiogenesis
Cellular Chloride Ion Homeostasis
Response To Lipopolysaccharide
Positive Regulation Of Apoptotic Process
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Neuron Apoptotic Process
Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Retinal Cell Programmed Cell Death
Endosomal Lumen Acidification
T Cell Apoptotic Process
Necroptotic Process
Response To Growth Factor
Apoptotic Signaling Pathway
Extrinsic Apoptotic Signaling Pathway
Necroptotic Signaling Pathway
Positive Regulation Of Endothelial Cell Apoptotic Process
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Negative Regulation Of Phosphatase Activity
Protein Ubiquitination
Pathways
Death Receptor Signalling
FasL/ CD95L signaling
Programmed Cell Death
Extrinsic Pathway
Drugs
Diseases
GWAS
Celiac disease (
20190752
)
Crohn's disease (
21102463
23128233
)
Protein-Protein Interactions
74 interactors:
APBB1
ARHGAP9
BAIAP2L1
BTK
CACNB3
CACNB4
CRK
DAXX
DLG2
DMD
DNMBP
DOCK4
EPS8L3
EZR
FADD
FAS
FGR
FN1
FNBP1
FYB
FYN
GRAP
GRAP2
GRB2
HCK
ITK
ITSN2
KALRN
KMT2A
KRT40
LCK
LYN
MACC1
MIA
MMP7
MPP4
MYO15A
NCF1
NCK1
NCK2
NCKIPSD
NOTCH2NL
OSTF1
PACSIN2
PDCD6
PIK3CA
PIK3R1
PIN1
PPIAP11
PRPF40A
PSTPIP1
PTPN13
RGS20
RIMBP3C
SAMSN1
SH3GL3
SH3PXD2A
SH3PXD2B
SH3RF2
SKAP2
SNX33
SNX9
SORBS3
SPTA1
SRC
SRGAP1
SRGAP2
SRGAP3
SUMO1
TEC
TJP3
TNFRSF6B
TRIP6
YES1
14 interactors:
AMOTL2
APP
BANP
FASLG
GOLGA2
HOMEZ
LZTS2
MTUS2
PAK4
PPP1CA
PPP1CC
RBPMS
SPERT
UBE2N
Entrez ID
356
153769
HPRD ID
00610
10229
Ensembl ID
ENSG00000117560
ENSG00000156463
Uniprot IDs
P48023
Q53ZZ1
Q08AM8
Q8TEC5
PDB IDs
1BZI
Enriched GO Terms of Interacting Partners
?
Immune Response-activating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Cell Surface Receptor Signaling Pathway
Immune Response-regulating Signaling Pathway
Fc Receptor Signaling Pathway
Peptidyl-tyrosine Autophosphorylation
Positive Regulation Of Immune Response
Antigen Receptor-mediated Signaling Pathway
Regulation Of Immune Response
Positive Regulation Of Immune System Process
Innate Immune Response
Immune System Process
Regulation Of Immune System Process
Regulation Of Cell Activation
Endocytosis
Positive Regulation Of Cell Activation
Immune Response
Regulation Of Cellular Process
T Cell Receptor Signaling Pathway
Axon Guidance
Regulation Of Lymphocyte Activation
Signal Transduction
Locomotion
Positive Regulation Of T Cell Activation
Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis
Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway
Fc Receptor Mediated Stimulatory Signaling Pathway
Fc-gamma Receptor Signaling Pathway
Positive Regulation Of Homotypic Cell-cell Adhesion
Defense Response
Movement Of Cell Or Subcellular Component
Positive Regulation Of Cell-cell Adhesion
Signaling
Regulation Of Signal Transduction
Cell Communication
Chemotaxis
T Cell Costimulation
Axonogenesis
Response To External Stimulus
Regulation Of T Cell Activation
Positive Regulation Of Cell Adhesion
Axon Development
Enzyme Linked Receptor Protein Signaling Pathway
Positive Regulation Of Metabolic Process
Vesicle-mediated Transport
Cell Morphogenesis Involved In Neuron Differentiation
Phagocytosis
Regulation Of Signaling
Cell Morphogenesis Involved In Differentiation
Cell Migration
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Triglyceride Catabolic Process
Entrainment Of Circadian Clock By Photoperiod
Photoperiodism
Entrainment Of Circadian Clock
Acylglycerol Catabolic Process
Regulation Of Signal Transduction
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway
Regulation Of Signaling
Cell Surface Receptor Signaling Pathway
Cell Cycle
Glycogen Metabolic Process
Response To Light Stimulus
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of Gene Expression
Circadian Regulation Of Gene Expression
Regulation Of ERBB Signaling Pathway
Polysaccharide Metabolic Process
Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Synaptic Growth At Neuromuscular Junction
Triglyceride Metabolic Process
Regulation Of Circadian Rhythm
Cell Division
Signal Transduction
Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Response To Radiation
Neutral Lipid Metabolic Process
Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway
Negative Regulation Of Cellular Response To Growth Factor Stimulus
Collateral Sprouting In Absence Of Injury
Endosomal Lumen Acidification
Positive Regulation Of Cellular Protein Metabolic Process
Signaling
Retinal Cell Programmed Cell Death
Regulation Of Histone Ubiquitination
Cell Communication
Energy Reserve Metabolic Process
Transforming Growth Factor Beta Receptor Signaling Pathway
Regulation Of Protein Binding
Collateral Sprouting
Axon Midline Choice Point Recognition
Positive Regulation Of Peptidase Activity
Positive Regulation Of Protein Metabolic Process
Cellular Lipid Catabolic Process
Cell Growth
Positive Regulation Of Signal Transduction
Regulation Of Protein Metabolic Process
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Necroptotic Signaling Pathway
Response To Growth Factor
Tagcloud
?
casp3
cl
coincided
corpora
cyclic
disaggregation
estrous
extrinsic
fos
ifng
ifngamma
jun
lutea
luteal
luteolysis
luteolytic
p4
pgf2alpha
postmortem
pregnancy
proportions
tnfa
tnfr1
tnfr2
tnfrsf1a
tnfrsf1b
viable
Tagcloud (Difference)
?
casp3
cl
coincided
corpora
cyclic
disaggregation
estrous
extrinsic
fos
ifng
ifngamma
jun
lutea
luteal
luteolysis
luteolytic
p4
pgf2alpha
postmortem
pregnancy
proportions
tnfa
tnfr1
tnfr2
tnfrsf1a
tnfrsf1b
viable
Tagcloud (Intersection)
?