FASLG and OSTF1

Number of citations of the paper that reports this interaction (PMID 19807924)
2

Data Source:
BioGRID (unspecified method)

		FASLG	OSTF1
Gene Name		Fas ligand (TNF superfamily, member 6)	osteoclast stimulating factor 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Lysosomal Lumen Perinuclear Region Of Cytoplasm Cytoplasmic Membrane-bounded Vesicle Lumen Extracellular Vesicular Exosome	Intracellular Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Receptor Binding Death Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Protein Binding SH3 Domain Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Cell Apoptotic Process Immune Response Signal Transduction Cell-cell Signaling Positive Regulation Of Cell Proliferation Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Angiogenesis Cellular Chloride Ion Homeostasis Response To Lipopolysaccharide Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Retinal Cell Programmed Cell Death Endosomal Lumen Acidification T Cell Apoptotic Process Necroptotic Process Response To Growth Factor Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Necroptotic Signaling Pathway Positive Regulation Of Endothelial Cell Apoptotic Process Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Ossification Signal Transduction
Pathways		Death Receptor Signalling FasL/ CD95L signaling Programmed Cell Death Extrinsic Pathway
Drugs
Diseases
GWAS		Celiac disease ( 20190752) Crohn's disease ( 21102463 23128233)
Protein-Protein Interactions		74 interactors: APBB1 ARHGAP9 BAIAP2L1 BTK CACNB3 CACNB4 CRK DAXX DLG2 DMD DNMBP DOCK4 EPS8L3 EZR FADD FAS FGR FN1 FNBP1 FYB FYN GRAP GRAP2 GRB2 HCK ITK ITSN2 KALRN KMT2A KRT40 LCK LYN MACC1 MIA MMP7 MPP4 MYO15A NCF1 NCK1 NCK2 NCKIPSD NOTCH2NL OSTF1 PACSIN2 PDCD6 PIK3CA PIK3R1 PIN1 PPIAP11 PRPF40A PSTPIP1 PTPN13 RGS20 RIMBP3C SAMSN1 SH3GL3 SH3PXD2A SH3PXD2B SH3RF2 SKAP2 SNX33 SNX9 SORBS3 SPTA1 SRC SRGAP1 SRGAP2 SRGAP3 SUMO1 TEC TJP3 TNFRSF6B TRIP6 YES1	12 interactors: APP CBL EFS FASLG GAPDH HTT KHDRBS1 MAPK6 REL SDCBP SMN1 TRIM54
Entrez ID		356	26578
HPRD ID		00610	17808
Ensembl ID		ENSG00000117560	ENSG00000134996
Uniprot IDs		P48023 Q53ZZ1	Q92882
PDB IDs		1BZI	1X2K 1ZLM 3EHQ 3EHR
Enriched GO Terms of Interacting Partners?		Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Fc Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Immune Response Positive Regulation Of Immune System Process Innate Immune Response Immune System Process Regulation Of Immune System Process Regulation Of Cell Activation Endocytosis Positive Regulation Of Cell Activation Immune Response Regulation Of Cellular Process T Cell Receptor Signaling Pathway Axon Guidance Regulation Of Lymphocyte Activation Signal Transduction Locomotion Positive Regulation Of T Cell Activation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of Homotypic Cell-cell Adhesion Defense Response Movement Of Cell Or Subcellular Component Positive Regulation Of Cell-cell Adhesion Signaling Regulation Of Signal Transduction Cell Communication Chemotaxis T Cell Costimulation Axonogenesis Response To External Stimulus Regulation Of T Cell Activation Positive Regulation Of Cell Adhesion Axon Development Enzyme Linked Receptor Protein Signaling Pathway Positive Regulation Of Metabolic Process Vesicle-mediated Transport Cell Morphogenesis Involved In Neuron Differentiation Phagocytosis Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Cell Migration Vascular Endothelial Growth Factor Receptor Signaling Pathway	Neuron Apoptotic Process Neuron Death Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Stimulus Regulation Of ERBB Signaling Pathway Signal Transduction Positive Regulation Of Signal Transduction Signaling Cell Communication Positive Regulation Of Intracellular Signal Transduction Response To Stimulus Regulation Of Signal Transduction Regulation Of Signaling Regulation Of Translation Axon Cargo Transport Mating Positive Regulation Of Transport Regulation Of Neuron Death Microtubule-based Process Visual Learning Visual Behavior Neural Plate Formation Peptidyl-cysteine S-trans-nitrosylation Associative Learning Synaptic Growth At Neuromuscular Junction Serotonin Uptake Positive Regulation Of RNA Export From Nucleus Lactate Biosynthetic Process From Pyruvate Apoptotic Process MRNA Processing Regulation Of Intracellular Signal Transduction Programmed Cell Death Posttranscriptional Regulation Of Gene Expression Cell Death Death Negative Regulation Of Cerebellar Granule Cell Precursor Proliferation Positive Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Collateral Sprouting In Absence Of Injury Regulation Of Protein Phosphatase Type 2A Activity Endosomal Lumen Acidification Regulation Of Receptor Activity Pyruvate Metabolic Process Positive Regulation Of Extracellular Vesicular Exosome Assembly Quinolinate Biosynthetic Process Negative Regulation Of Synaptic Transmission, Dopaminergic Retinal Cell Programmed Cell Death Microtubule-based Transport MRNA Metabolic Process Learning Cytoskeleton-dependent Intracellular Transport
Tagcloud ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	acad euryhaline fiol gills gilz hyperosmolality hyperosmotic hypertonicity kultz mimcd3 mosmol mossambicus natl oreochromis orthologs osmolytes osmosensory osmotic papilla proc tilapia tsc22d tsc22d1 tsc22d2 tsc22d3 tsc22d4 unresponsive usa102 zipper
Tagcloud (Difference) ?		casp3 cl coincided corpora cyclic disaggregation estrous extrinsic fos ifng ifngamma jun lutea luteal luteolysis luteolytic p4 pgf2alpha postmortem pregnancy proportions tnfa tnfr1 tnfr2 tnfrsf1a tnfrsf1b viable	acad euryhaline fiol gills gilz hyperosmolality hyperosmotic hypertonicity kultz mimcd3 mosmol mossambicus natl oreochromis orthologs osmolytes osmosensory osmotic papilla proc tilapia tsc22d tsc22d1 tsc22d2 tsc22d3 tsc22d4 unresponsive usa102 zipper
Tagcloud (Intersection) ?