SH3GL3 and GABBR2

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SH3GL3	GABBR2
Gene Name		SH3-domain GRB2-like 3	gamma-aminobutyric acid (GABA) B receptor, 2
Image
Gene Ontology Annotations	Cellular Component	Early Endosome Membrane Extracellular Vesicular Exosome	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction G-protein Coupled Receptor Heterodimeric Complex Neuron Projection Postsynaptic Membrane
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	G-protein Coupled GABA Receptor Activity Protein Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development	G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Synaptic Transmission
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Inwardly rectifying K+ channels GABA B receptor activation Signaling by GPCR GABA receptor activation Activation of G protein gated Potassium channels Activation of GABAB receptors Potassium Channels Metabolic disorders of biological oxidation enzymes GPCR ligand binding G protein gated Potassium channels Class C/3 (Metabotropic glutamate/pheromone receptors) GPCR downstream signaling G alpha (i) signalling events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Height ( 18391950 18391951 20397748)	Post-traumatic stress disorder (asjusted for relatedness) ( 23726511)
Protein-Protein Interactions		44 interactors: ADRB1 AES ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNM1 DPPA4 DPYSL4 EGFL6 EMD FAM173A FASLG GABBR2 HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RBM48 RER1 RPL35A SEPT8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TNNT1 TOE1 VIM WASL WDR33	9 interactors: ATF4 ATF5 GABBR1 GLP1R GRASP HTR1A KCTD12 NSF SH3GL3
Entrez ID		6457	9568
HPRD ID		04528	09552
Ensembl ID		ENSG00000140600	ENSG00000136928
Uniprot IDs		Q99963	H9NIL8 O75899
PDB IDs		2EW3 2Z0V	4F11 4F12
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signaling Regulation Of ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Signaling Signal Transduction Vesicle-mediated Transport Cell Communication Movement Of Cell Or Subcellular Component Regulation Of Vesicle-mediated Transport Response To Stimulus Cellular Response To Stimulus Cell Death Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Membrane Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process System Development Neuron Development Apoptotic Process Cellular Process Generation Of Neurons Actin Filament-based Movement Multicellular Organismal Development Nervous System Development Programmed Cell Death Regulation Of Signaling Neurogenesis Regulation Of Endocytosis Regulation Of Signal Transduction Negative Regulation Of Neuron Differentiation Neuron Projection Development Establishment Of Vesicle Localization Synaptic Transmission Positive Regulation Of Apoptotic Process Cell Projection Morphogenesis Neuron Differentiation Vesicle Localization Response To Growth Factor Axon Guidance Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis	Gamma-aminobutyric Acid Signaling Pathway Regulation Of Adenylate Cyclase Activity Adenylate Cyclase-inhibiting G-protein Coupled Receptor Signaling Pathway Regulation Of Cyclase Activity Regulation Of CAMP Biosynthetic Process G-protein Coupled Receptor Signaling Pathway Regulation Of CAMP Metabolic Process Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Golgi Vesicle Docking Signaling Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway Cell Communication G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Regulation Of Secretion Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Circadian Rhythm Regulation Of Cellular Process Regulation Of Serotonin Secretion Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress Olfactory Bulb Interneuron Development Negative Regulation Of Oxidative Stress-induced Neuron Death Regulation Of Hormone Secretion Positive Regulation Of Transcription From RNA Polymerase I Promoter Signal Transduction Olfactory Bulb Interneuron Differentiation Negative Regulation Of Astrocyte Differentiation Serotonin Receptor Signaling Pathway Serotonin Metabolic Process Rhythmic Process Regulation Of Cellular Localization Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Receptor Recycling Regulation Of Dopamine Metabolic Process Plasma Membrane Fusion Regulation Of Transcription From RNA Polymerase I Promoter Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress
Tagcloud ?		85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Difference) ?		85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish	a432t a452v ankk1 arrb2 cdh13 chrna2 chrna9 dbh dnm1 drd2 eas fagerstrom grin3a mstcc n549s nrxn1 nrxn2 nrxn3 ntrk2 r480h rs139982841 rs142807401 rs34755188 rs75981117 skat tas2r38 v132l v389l wss
Tagcloud (Intersection) ?