CDC34 and FBXO32

Data Source:
BioGRID (pull down)

		CDC34	FBXO32
Description		cell division cycle 34, ubiqiutin conjugating enzyme	F-box protein 32
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Speck	Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex Z Disc
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Protein Polyubiquitination DNA Replication Initiation Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Cellular Response To Interferon-beta Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Neuron Apoptotic Process Negative Regulation Of CAMP-mediated Signaling Response To Growth Factor Protein K48-linked Ubiquitination Positive Regulation Of Inclusion Body Assembly	Protein Polyubiquitination Response To Denervation Involved In Regulation Of Muscle Adaptation Protein Ubiquitination Post-translational Protein Modification Cellular Response To Dexamethasone Stimulus
Pathways		Downstream TCR signaling FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Neddylation FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Atrial fibrillation ( 30061737 29892015) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29617998 29785010 31959993 30054594) Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603)
Interacting Genes		56 interacting genes: ATF5 BTRC CCNB1 CDK9 CDKN1B CREM CSNK2B CTNNB1 CUL1 CUL2 CUL3 EGFR FBXL2 FBXL3 FBXO32 FBXO4 FBXO7 FBXW2 FBXW7 HIF1A ING4 ITCH MARCHF1 MARCHF2 MDM2 MEOX1 MEOX2 MUL1 MYBL2 MYOD1 NEDD4L NEDD8 NFKBIA PPARA PPARG PRKN PTTG1 RBX1 RELA RNF31 RNF7 ROCK1 SDCBP SIAH1 SKP2 TBL1X TP53 TRIM21 TRIM28 TRIM29 UBA1 UBB VHL WWP2 ZFAND6 ZNRF1	10 interacting genes: CDC34 EIF3F KDM2A MLH1 MYOD1 MYOG SH3GL1 SH3GL2 SH3GL3 SKP1
Entrez ID		997	114907
HPRD ID		00306	05966
Ensembl ID		ENSG00000099804	ENSG00000156804
Uniprot IDs		A0A024R1Z1 P49427	A0A024R9F3 I6L984 Q0VAQ6 Q498Y9 Q969P5
PDB IDs		2OB4 3RZ3 4MDK
Enriched GO Terms of Interacting Partners?
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