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CDC34 and ROCK1
Data Source:
HPRD
(in vitro)
CDC34
ROCK1
Description
cell division cycle 34, ubiqiutin conjugating enzyme
Rho associated coiled-coil containing protein kinase 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Nuclear Speck
Golgi Membrane
Ruffle
Extracellular Region
Cytoplasm
Centriole
Cytosol
Cytoskeleton
Plasma Membrane
Cytoplasmic Stress Granule
Lamellipodium
Bleb
Secretory Granule Lumen
Amyloid-beta Complex
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Conjugating Enzyme Activity
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Aspartic-type Endopeptidase Inhibitor Activity
Metal Ion Binding
Tau Protein Binding
Tau-protein Kinase Activity
Rho-dependent Protein Serine/threonine Kinase Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
DNA Replication Initiation
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Cellular Response To Interferon-beta
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of CAMP-mediated Signaling
Response To Growth Factor
Protein K48-linked Ubiquitination
Positive Regulation Of Inclusion Body Assembly
Mitotic Cytokinesis
Aortic Valve Morphogenesis
Protein Phosphorylation
Apoptotic Process
Smooth Muscle Contraction
Leukocyte Cell-cell Adhesion
Signal Transduction
G Protein-coupled Receptor Signaling Pathway
I-kappaB Kinase/NF-kappaB Signaling
Rho Protein Signal Transduction
Regulation Of Autophagy
Positive Regulation Of Autophagy
Positive Regulation Of Cardiac Muscle Hypertrophy
Positive Regulation Of Gene Expression
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of Angiogenesis
Peptidyl-serine Phosphorylation
Peptidyl-threonine Phosphorylation
Membrane To Membrane Docking
Actin Cytoskeleton Organization
Regulation Of Cell Adhesion
Regulation Of Cell Migration
Cortical Actin Cytoskeleton Organization
Actomyosin Structure Organization
Neuron Projection Development
Negative Regulation Of Protein Binding
Regulation Of Actin Cytoskeleton Organization
Negative Regulation Of Myosin-light-chain-phosphatase Activity
Negative Regulation Of Phosphorylation
Neutrophil Degranulation
Positive Regulation Of MAPK Cascade
Regulation Of Keratinocyte Differentiation
Regulation Of Neuron Differentiation
Vascular Endothelial Growth Factor Receptor Signaling Pathway
Ephrin Receptor Signaling Pathway
Embryonic Morphogenesis
Leukocyte Migration
Leukocyte Tethering Or Rolling
Negative Regulation Of Membrane Protein Ectodomain Proteolysis
Myoblast Migration
Regulation Of Stress Fiber Assembly
Regulation Of Focal Adhesion Assembly
Positive Regulation Of Focal Adhesion Assembly
MRNA Destabilization
Negative Regulation Of Biomineral Tissue Development
Regulation Of Microtubule Cytoskeleton Organization
Response To Transforming Growth Factor Beta
Protein Localization To Plasma Membrane
Glomerular Visceral Epithelial Cell Migration
Blood Vessel Diameter Maintenance
Regulation Of Angiotensin-activated Signaling Pathway
Neuron Projection Arborization
Positive Regulation Of Amyloid-beta Clearance
Regulation Of Synaptic Vesicle Endocytosis
Regulation Of Cell Junction Assembly
Regulation Of Amyloid-beta Formation
Negative Regulation Of Amyloid-beta Formation
Negative Regulation Of Amyloid Precursor Protein Catabolic Process
Regulation Of Establishment Of Endothelial Barrier
Negative Regulation Of Bicellular Tight Junction Assembly
Positive Regulation Of Connective Tissue Replacement
Response To Angiotensin
Regulation Of Establishment Of Cell Polarity
Regulation Of Cell Motility
Pathways
Downstream TCR signaling
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
Apoptotic cleavage of cellular proteins
EPHB-mediated forward signaling
EPHB-mediated forward signaling
EPHA-mediated growth cone collapse
G alpha (12/13) signalling events
Sema4D induced cell migration and growth-cone collapse
Sema4D induced cell migration and growth-cone collapse
VEGFA-VEGFR2 Pathway
RHO GTPases Activate ROCKs
RHO GTPases Activate ROCKs
Neutrophil degranulation
RHOBTB1 GTPase cycle
Potential therapeutics for SARS
Drugs
Hydroxyfasudil
(S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE
Fasudil
Y-27632
Ripasudil
Netarsudil
Diseases
GWAS
Asthma exacerbations in inhaled corticosteroid treatment (
30697902
)
Lysophosphatidylcholine levels (
31551469
)
Telomere length (
30185882
)
Interacting Genes
56 interacting genes:
ATF5
BTRC
CCNB1
CDK9
CDKN1B
CREM
CSNK2B
CTNNB1
CUL1
CUL2
CUL3
EGFR
FBXL2
FBXL3
FBXO32
FBXO4
FBXO7
FBXW2
FBXW7
HIF1A
ING4
ITCH
MARCHF1
MARCHF2
MDM2
MEOX1
MEOX2
MUL1
MYBL2
MYOD1
NEDD4L
NEDD8
NFKBIA
PPARA
PPARG
PRKN
PTTG1
RBX1
RELA
RNF31
RNF7
ROCK1
SDCBP
SIAH1
SKP2
TBL1X
TP53
TRIM21
TRIM28
TRIM29
UBA1
UBB
VHL
WWP2
ZFAND6
ZNRF1
36 interacting genes:
ADD1
ARHGAP24
CASP3
CASP7
CDC25A
CDC34
CFAP206
CRMP1
DES
DPYSL2
EZR
FAM124A
GFAP
IKBKB
IRS1
ITSN2
LIMK1
LIMK2
LMO2
MAGEB4
MLC1
MSN
PFN2
POLR3C
PPP1R12A
PTK2
RDX
RHOA
RHOC
RND3
SMAD2
TPPP
TRIM15
TSG101
UBE2T
VIM
Entrez ID
997
6093
HPRD ID
00306
03414
Ensembl ID
ENSG00000099804
ENSG00000067900
Uniprot IDs
A0A024R1Z1
P49427
Q13464
PDB IDs
2OB4
3RZ3
4MDK
1S1C
2ESM
2ETK
2ETR
2V55
3D9V
3NCZ
3NDM
3O0Z
3TV7
3TWJ
3V8S
4L2W
4W7P
4YVC
4YVE
5BML
5F5P
5HVU
5KKS
5KKT
5UZJ
5WNE
5WNF
5WNG
5WNH
6E9W
7JOU
Enriched GO Terms of Interacting Partners
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