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FBXO32 and SKP1
Data Source:
HPRD
(in vitro, in vivo)
FBXO32
SKP1
Description
F-box protein 32
S-phase kinase associated protein 1
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Z Disc
Nucleus
Nucleoplasm
Cytoplasm
Centrosome
Cytosol
SCF Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
PcG Protein Complex
Molecular Function
Protein Binding
Protein Binding
Beta-catenin Binding
Protein Domain Specific Binding
Cullin Family Protein Binding
F-box Domain Binding
Ubiquitin Ligase-substrate Adaptor Activity
Biological Process
Protein Polyubiquitination
Response To Denervation Involved In Regulation Of Muscle Adaptation
Protein Ubiquitination
Post-translational Protein Modification
Cellular Response To Dexamethasone Stimulus
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Cellular Iron Ion Homeostasis
SCF Complex Assembly
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Histone H2A Monoubiquitination
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Maintenance Of Protein Location In Nucleus
Interleukin-1-mediated Signaling Pathway
Protein K48-linked Ubiquitination
Regulation Of Mitotic Cell Cycle Phase Transition
Positive Regulation Of Ubiquitin Protein Ligase Activity
Pathways
Neddylation
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Antigen processing: Ubiquitination & Proteasome degradation
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
Vpu mediated degradation of CD4
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK-->noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
1-naphthaleneacetic acid
(2S)-2-(1H-indol-3-yl)hexanoic acid
(2S)-2-(1H-indol-3-yl)pentanoic acid
(2S)-8-[(tert-butoxycarbonyl)amino]-2-(1H-indol-3-yl)octanoic acid
Indoleacetic acid
Diseases
GWAS
Atrial fibrillation (
30061737
29892015
)
Electrocardiogram morphology (amplitude at temporal datapoints) (
32916098
)
Glaucoma (
30054594
)
Glaucoma (primary open-angle) (
29891935
)
Intraocular pressure (
29617998
29785010
31959993
30054594
)
Psychosis proneness (hypomanic personality scale and perceptual aberration scale) (
28525603
)
Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) (
28525603
)
Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) (
28525603
)
Psychosis proneness (hypomanic personality scale) (
28525603
)
Mean platelet volume (
32888494
)
Systemic lupus erythematosus (
27399966
26502338
)
Interacting Genes
10 interacting genes:
CDC34
EIF3F
KDM2A
MLH1
MYOD1
MYOG
SH3GL1
SH3GL2
SH3GL3
SKP1
80 interacting genes:
ANKRD36BP1
APIP
BTRC
CACYBP
CAND1
CCNA2
CDCA3
CDK2
CDK4
CDK9
CDKN1A
CDKN1B
CENPE
CUL1
CUL7
DDX19B
FBH1
FBXL14
FBXL2
FBXL20
FBXL22
FBXL3
FBXL4
FBXL5
FBXL6
FBXL8
FBXO11
FBXO15
FBXO16
FBXO17
FBXO2
FBXO25
FBXO27
FBXO28
FBXO3
FBXO32
FBXO34
FBXO4
FBXO43
FBXO44
FBXO46
FBXO48
FBXO5
FBXO6
FBXO7
FBXO8
FBXO9
FBXW2
FBXW5
FBXW7
FBXW8
GHR
GLMN
GPS1
HSP90AA1
KCTD9
LAMTOR5
LMO2
MED21
MEOX2
MTUS1
MYC
NFKBIA
NFKBIB
NFKBIE
NUDT9P1
PPARGC1A
PPP1CA
PTEN
RBX1
SEC23B
SKP2
SUGT1
TBL1X
TERF1
TRRAP
TTC21A
TTC9C
UBE2D1
UHRF2
Entrez ID
114907
6500
HPRD ID
05966
03255
Ensembl ID
ENSG00000156804
ENSG00000113558
Uniprot IDs
A0A024R9F3
I6L984
Q0VAQ6
Q498Y9
Q969P5
P63208
PDB IDs
1FQV
1FS1
1FS2
1LDK
1P22
2ASS
2AST
2E31
2E32
2OVP
2OVQ
2OVR
3L2O
3WSO
4I6J
5IBK
5JH5
5K35
5V4B
5VZT
5VZU
5XYL
6BVA
6BYH
6C16
6M90
6M91
6M92
6M93
6M94
6O60
6TTU
6VCD
6W66
6WCQ
6WNX
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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