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CDC34 and PPARA
Data Source:
BioGRID
(pull down)
CDC34
PPARA
Description
cell division cycle 34, ubiqiutin conjugating enzyme
peroxisome proliferator activated receptor alpha
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytosol
Nuclear Speck
Chromatin
Nucleus
Nucleoplasm
Molecular Function
Ubiquitin-protein Transferase Activity
Protein Binding
ATP Binding
Ubiquitin Conjugating Enzyme Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
RNA Polymerase II Repressing Transcription Factor Binding
Transcription Coactivator Binding
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Steroid Hormone Receptor Activity
Nuclear Receptor Activity
Protein Binding
Transcription Factor Binding
Drug Binding
Zinc Ion Binding
Lipid Binding
Phosphatase Binding
Protein Domain Specific Binding
Ubiquitin Conjugating Enzyme Binding
Sequence-specific DNA Binding
Protein-containing Complex Binding
NFAT Protein Binding
MDM2/MDM4 Family Protein Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
DNA Replication Initiation
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Protein Ubiquitination
Cellular Response To Interferon-beta
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Neuron Apoptotic Process
Negative Regulation Of CAMP-mediated Signaling
Response To Growth Factor
Protein K48-linked Ubiquitination
Positive Regulation Of Inclusion Body Assembly
Negative Regulation Of Transcription By RNA Polymerase II
Response To Hypoxia
Transcription Initiation From RNA Polymerase II Promoter
Fatty Acid Metabolic Process
Heart Development
Epidermis Development
Cellular Response To Starvation
Hormone-mediated Signaling Pathway
Regulation Of Cellular Ketone Metabolic Process
Negative Regulation Of Macrophage Derived Foam Cell Differentiation
Lipid Localization
Negative Regulation Of Cholesterol Storage
Negative Regulation Of Sequestering Of Triglyceride
Regulation Of Lipid Metabolic Process
Regulation Of Fatty Acid Metabolic Process
Cell Differentiation
Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway
Intracellular Receptor Signaling Pathway
Positive Regulation Of Fatty Acid Beta-oxidation
Negative Regulation Of Protein Binding
Negative Regulation Of Appetite
Response To Insulin
Circadian Regulation Of Gene Expression
Response To Lipid
Behavioral Response To Nicotine
Wound Healing
Lipoprotein Metabolic Process
Regulation Of Circadian Rhythm
Steroid Hormone Mediated Signaling Pathway
Positive Regulation Of Viral Genome Replication
Response To Ethanol
Positive Regulation Of Gluconeogenesis
Negative Regulation Of Blood Pressure
Negative Regulation Of Glycolytic Process
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Fatty Acid Metabolic Process
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Fatty Acid Oxidation
Positive Regulation Of Lipid Biosynthetic Process
Negative Regulation Of Inflammatory Response
Negative Regulation Of Protein Kinase B Signaling
Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development
Enamel Mineralization
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Negative Regulation Of Neuron Death
Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Negative Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Hepatocyte Apoptotic Process
Regulation Of Fatty Acid Transport
Negative Regulation Of Signaling Receptor Activity
Positive Regulation Of ATP Biosynthetic Process
Pathways
Downstream TCR signaling
FCERI mediated NF-kB activation
CLEC7A (Dectin-1) signaling
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
Antigen processing: Ubiquitination & Proteasome degradation
RORA activates gene expression
BMAL1:CLOCK,NPAS2 activates circadian gene expression
PPARA activates gene expression
PPARA activates gene expression
Transcriptional activation of mitochondrial biogenesis
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
Nuclear Receptor transcription pathway
Regulation of lipid metabolism by PPARalpha
Circadian Clock
SUMOylation of intracellular receptors
Drugs
alpha-Linolenic acid
Icosapent
Troglitazone
Valproic acid
Indomethacin
Rosiglitazone
Fenoprofen
Clofibrate
Fenofibrate
Ibuprofen
Amiodarone
Gemfibrozil
Bezafibrate
Prasterone
N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide
Flufenamic acid
Resveratrol
Phthalic Acid
Lauric acid
Stearic acid
Doconexent
Palmitic Acid
Oleic Acid
Caprylic acid
Arachidonic Acid
Reglitazar
Elafibranor
Cardarine
Muraglitazar
Ertiprotafib
Ragaglitazar
Tesaglitazar
GW-590735
Indeglitazar
Myristic acid
Aleglitazar
Clinofibrate
Ciprofibrate
Dexibuprofen
Soybean oil
Omega-3 fatty acids
Myrrh
Isoflavone
Leukotriene B4
Fenofibric acid
Fish oil
Diseases
GWAS
Cholesterol, total (
24097068
)
CTACK levels (
27989323
)
Eosinophil counts (
32888494
)
Eosinophil percentage of white cells (
32888494
)
Impulsivity (motor) (
30718321
)
LDL cholesterol (
24097068
)
Refractive error (
32231278
)
Resting-state electroencephalogram vigilance (
29703947
)
Triglyceride levels (
32203549
)
Type 2 diabetes (
31049640
)
Very long-chain saturated fatty acid levels (fatty acid 20:0) (
25378659
)
Interacting Genes
56 interacting genes:
ATF5
BTRC
CCNB1
CDK9
CDKN1B
CREM
CSNK2B
CTNNB1
CUL1
CUL2
CUL3
EGFR
FBXL2
FBXL3
FBXO32
FBXO4
FBXO7
FBXW2
FBXW7
HIF1A
ING4
ITCH
MARCHF1
MARCHF2
MDM2
MEOX1
MEOX2
MUL1
MYBL2
MYOD1
NEDD4L
NEDD8
NFKBIA
PPARA
PPARG
PRKN
PTTG1
RBX1
RELA
RNF31
RNF7
ROCK1
SDCBP
SIAH1
SKP2
TBL1X
TP53
TRIM21
TRIM28
TRIM29
UBA1
UBB
VHL
WWP2
ZFAND6
ZNRF1
70 interacting genes:
AIP
AKAP13
ANKRD11
AQP1
BCL2
CCDC179
CDC34
CDK3
CEP350
CHD9
CHIC2
COL8A1
CTNNA3
DAP3
DUT
EP300
EXOSC4
FABP1
FAM90A1
FAM9B
FBLN1
FOXA3
GADD45A
GADD45B
GADD45G
GPANK1
HELZ2
HOXC8
HSP90AA1
KCTD7
KRTAP10-1
LAMTOR5
MAPK1
MAPK3
MECR
MED1
MED24
NCOA1
NCOA2
NCOA3
NCOR1
NCOR2
NR1H2
NR1H3
NRBF2
NRIP1
PAQR3
PICK1
PIK3R3
POU1F1
PPARGC1A
PPARGC1B
PRKCA
PRKCD
PRMT1
PRMT8
RELA
RXRA
RXRG
SDCBP
SIRT1
STAC3
TNP1
TRIM55
TRIM63
UBE2I
VWA5A
VWC2L
ZNF587
ZSCAN23
Entrez ID
997
5465
HPRD ID
00306
01369
Ensembl ID
ENSG00000099804
ENSG00000186951
Uniprot IDs
A0A024R1Z1
P49427
F1D8S4
Q07869
PDB IDs
2OB4
3RZ3
4MDK
1I7G
1K7L
1KKQ
2NPA
2P54
2REW
2ZNN
3ET1
3FEI
3G8I
3KDT
3KDU
3SP6
3VI8
4BCR
4CI4
5AZT
5HYK
6KXX
6KXY
6L96
Enriched GO Terms of Interacting Partners
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