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CASP6 and PSEN2
Data Source:
HPRD
(in vivo, in vitro)
CASP6
PSEN2
Description
caspase 6
presenilin 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Golgi Membrane
Kinetochore
Nucleus
Nuclear Inner Membrane
Mitochondrial Inner Membrane
Lysosomal Membrane
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Golgi Apparatus
Centrosome
Plasma Membrane
Integral Component Of Plasma Membrane
Cell Cortex
Cell Surface
Membrane
Apical Plasma Membrane
Z Disc
Growth Cone
Neuromuscular Junction
Protein-containing Complex
Ciliary Rootlet
Neuronal Cell Body
Dendritic Shaft
Membrane Raft
Perinuclear Region Of Cytoplasm
Gamma-secretase Complex
Molecular Function
Cysteine-type Endopeptidase Activity
Protein Binding
Cysteine-type Peptidase Activity
Identical Protein Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Endopeptidase Activity
Protein Binding
Aspartic Endopeptidase Activity, Intramembrane Cleaving
Biological Process
Proteolysis
Apoptotic Process
Epithelial Cell Differentiation
Regulation Of Apoptotic Process
Cellular Response To Staurosporine
Execution Phase Of Apoptosis
Membrane Protein Ectodomain Proteolysis
Calcium Ion Transport
Notch Receptor Processing
Protein Processing
Membrane Protein Intracellular Domain Proteolysis
Amyloid-beta Formation
Notch Receptor Processing, Ligand-dependent
Intracellular Signal Transduction
Amyloid Precursor Protein Catabolic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Positive Regulation Of Catalytic Activity
Ephrin Receptor Signaling Pathway
Amyloid-beta Metabolic Process
Regulation Of Calcium Import Into The Mitochondrion
Mitochondrion-endoplasmic Reticulum Membrane Tethering
Pathways
Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins
Breakdown of the nuclear lamina
TP53 Regulates Transcription of Caspase Activators and Caspases
Nuclear signaling by ERBB4
Regulated proteolysis of p75NTR
NRIF signals cell death from the nucleus
Activated NOTCH1 Transmits Signal to the Nucleus
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
NOTCH2 Activation and Transmission of Signal to the Nucleus
EPH-ephrin mediated repulsion of cells
NOTCH3 Activation and Transmission of Signal to the Nucleus
NOTCH4 Activation and Transmission of Signal to the Nucleus
Noncanonical activation of NOTCH3
Drugs
Diseases
Alzheimer's disease (AD)
GWAS
Risk-taking tendency (4-domain principal component model) (
30643258
)
Heel bone mineral density (
30598549
)
Refractive error (
32231278
)
Interacting Genes
42 interacting genes:
APP
CASP10
CASP3
CASP8
CFLAR
CHD3
COPS6
DSP
EIF2S1
HTT
IKBKG
KRT18
LMNA
LMNB1
LNX1
MAPK6
MAPT
NEDD4
NTAQ1
NUAK1
PCYT1A
PIN1
PKIA
PPL
PRKAB2
PRKCZ
PSEN1
PSEN2
PSME3
RB1
SATB1
SP1
SRF
SRP72
STUB1
TAB1
TFAP2A
TOP1
TRAF1
UBE4A
UBE4B
VIM
61 interacting genes:
AAMP
ACTG1
AP1G1
APH1A
APH1B
APP
AURKA
BCL2L1
CAPN1
CASP1
CASP3
CASP6
CASP7
CASP8
CEP55
CFLAR
CHKA
CIB1
CSNK1A1
CSNK1D
CSNK2A1
CTNNB1
CTNND2
DNAJB1
DOCK3
ECD
EID1
ELAVL1
EVI5L
EXOC6
FBXL12
FHL2
FLNA
FLNB
GCDH
GFAP
HLA-DMB
HPS1
ICAM5
IFIT3
IFIT5
KCNIP3
KCNIP4
LIPF
MAST1
METTL2B
NCSTN
NOS3
NOTCH1
NOTCH2
NOTCH3
NOTCH4
OGA
PDCD4
PSENEN
RAB11A
RHEB
RNF32
SPC24
SRI
UBQLN1
Entrez ID
839
5664
HPRD ID
03321
02860
Ensembl ID
ENSG00000138794
ENSG00000143801
Uniprot IDs
P55212
P49810
PDB IDs
1MI9
2WDP
3K7E
3NKF
3NR2
3OD5
3P45
3P4U
3QNW
3S70
3S8E
3V6L
3V6M
4EJF
4FXO
4HVA
4IYR
4N5D
4N6G
4N7J
4N7M
4NBK
4NBL
4NBN
6DEU
6DEV
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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