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CASP6 and PRKAB2
Data Source:
BioGRID
(two hybrid)
CASP6
PRKAB2
Description
caspase 6
protein kinase AMP-activated non-catalytic subunit beta 2
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Nucleotide-activated Protein Kinase Complex
Molecular Function
Cysteine-type Endopeptidase Activity
Protein Binding
Cysteine-type Peptidase Activity
Identical Protein Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
AMP-activated Protein Kinase Activity
Protein Binding
Protein Kinase Binding
Identical Protein Binding
Biological Process
Proteolysis
Apoptotic Process
Epithelial Cell Differentiation
Regulation Of Apoptotic Process
Cellular Response To Staurosporine
Execution Phase Of Apoptosis
Protein Phosphorylation
Fatty Acid Biosynthetic Process
Carnitine Shuttle
Cell Cycle Arrest
Signal Transduction
Macroautophagy
Regulation Of Macroautophagy
Regulation Of Fatty Acid Biosynthetic Process
Regulation Of Catalytic Activity
Regulation Of Primary Metabolic Process
Positive Regulation Of Cold-induced Thermogenesis
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Apoptotic cleavage of cellular proteins
Caspase-mediated cleavage of cytoskeletal proteins
Breakdown of the nuclear lamina
TP53 Regulates Transcription of Caspase Activators and Caspases
Translocation of SLC2A4 (GLUT4) to the plasma membrane
Macroautophagy
AMPK inhibits chREBP transcriptional activation activity
AMPK inhibits chREBP transcriptional activation activity
Carnitine metabolism
Activation of PPARGC1A (PGC-1alpha) by phosphorylation
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Lipophagy
Activation of AMPK downstream of NMDARs
Drugs
Adenosine phosphate
Acetylsalicylic acid
Fostamatinib
Diseases
GWAS
Risk-taking tendency (4-domain principal component model) (
30643258
)
Interacting Genes
42 interacting genes:
APP
CASP10
CASP3
CASP8
CFLAR
CHD3
COPS6
DSP
EIF2S1
HTT
IKBKG
KRT18
LMNA
LMNB1
LNX1
MAPK6
MAPT
NEDD4
NTAQ1
NUAK1
PCYT1A
PIN1
PKIA
PPL
PRKAB2
PRKCZ
PSEN1
PSEN2
PSME3
RB1
SATB1
SP1
SRF
SRP72
STUB1
TAB1
TFAP2A
TOP1
TRAF1
UBE4A
UBE4B
VIM
170 interacting genes:
ABHD11
ADAMTSL4
ANAPC11
ARID5A
AUNIP
AVP
BANP
BEND5
BHLHB9
BLZF1
C11orf1
C19orf54
C2orf42
C3orf36
CALCOCO2
CASP2
CASP6
CCDC28B
CCDC33
CDC14B
CDSN
CDX4
CFP
CREB3L1
CRX
CSNK2B
CYSRT1
DAO
DDAH2
DDIT4L
DICER1
DOK3
DST
ELL2
EPM2A
ESM1
FDX1
FLNC
GATA1
GATAD2B
GCSAML
GET4
GOLGA2
GOLGA6L9
GORASP2
GRAPL
GRN
GSC2
IHO1
IKZF1
IKZF3
IL37
IRAK1BP1
KATNBL1
KCTD5
KHDC4
KLF15
KRBOX4
KRT31
KRT40
KRTAP1-1
KRTAP1-3
KRTAP10-11
KRTAP10-3
KRTAP10-5
KRTAP10-7
KRTAP10-8
KRTAP10-9
KRTAP17-1
KRTAP2-3
KRTAP2-4
KRTAP3-3
KRTAP4-12
KRTAP4-2
KRTAP4-5
KRTAP5-9
KRTAP9-2
KRTAP9-3
KRTAP9-4
KRTAP9-8
LHX3
LRIF1
LZTS1
LZTS2
MAGED1
MAJIN
MDFI
MEOX2
METTL27
MORN3
NAB2
NEBL
NHLRC4
NUTM1
OXER1
PDE6G
PDE6H
PFDN5
PIAS2
PNMA1
PPP1R13B
PPP1R16A
PRDM14
PRKAA1
PRKAG1
PRKAG2
PSMD11
PSME3
PYGM
QKI
RAB3IP
RACK1
RBM48
RBPMS
REL
RHEBL1
RIMBP3
RNF144B
ROR2
RPH3AL
SAMD4A
SERTAD2
SMARCB1
SMUG1
SPRY1
SPRY2
SSC4D
SSX2IP
STX11
STX19
TADA2A
TASOR2
TCF12
TCF19
TCF4
TCF7L2
TGM7
TLE5
TNNI1
TP53
TP53BP2
TRAF1
TRAF2
TRIB3
TRIM10
TRIM14
TRIM35
TRIM42
TRIM54
TRIM55
TRIM63
TSR2
TTC23
UBXN11
USP54
VBP1
VPS28
WDR83
YPEL3
YY1AP1
ZBTB32
ZC2HC1C
ZFP90
ZMYND19
ZNF177
ZNF236
ZNF474
ZNF526
ZNF559-ZNF177
ZNF581
Entrez ID
839
5565
HPRD ID
03321
04117
Ensembl ID
ENSG00000138794
ENSG00000131791
Uniprot IDs
P55212
O43741
PDB IDs
1MI9
2WDP
3K7E
3NKF
3NR2
3OD5
3P45
3P4U
3QNW
3S70
3S8E
3V6L
3V6M
4EJF
4FXO
4HVA
4IYR
4N5D
4N6G
4N7J
4N7M
4NBK
4NBL
4NBN
6DEU
6DEV
2F15
2V8Q
2V92
2V9J
2Y8L
2Y8Q
2YA3
4CFH
4EAI
4EAJ
4RER
4REW
6B2E
Enriched GO Terms of Interacting Partners
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